SIRT3 is a NAD+-dependent deacetylase that regulates the function of numerous
mitochondrial proteins with roles in metabolism, oxidative stress, and cell survival. It is …

Sirt1 is the most prominent and extensively studied member of sirtuins, the family of
mammalian class III histone deacetylases heavily implicated in health span and longevity …

Abstract Sirtuins (SIRT1–7) are distinct histone deacetylases (HDACs) whose activity is
determined by cellular metabolic status andnicotinamide adenine dinucleotide (NAD+) …

Sirtuin 3 (SIRT3) deacetylates and regulates many mitochondrial proteins to maintain health,
but its functions are depressed in aging and obesity. The best-studied sirtuin, SIRT1 …

Significance: It is a well-established scientific observation that mammalian cells contain
fidelity or watchdog proteins that maintain the correct function of cellular organelles. Recent …

Maintaining metabolic homeostasis is essential for cellular and organismal health
throughout life. Multiple signaling pathways that regulate metabolism also play critical roles …

The sirtuins are highly conserved NAD‐dependent deacetylases that were shown to
regulate lifespan in lower organisms and affect diseases of aging in mammals, such as …

Sirtuin enzymes are a family of highly seven conserved protein deacetylases, namely SIRT1
through SIRT7, whose enzymatic activities require the cofactor nicotinamide adenine …

In eukaryotes, mitochondria carry out numerous functions that are central to cellular and
organismal health. How mitochondrial activities are regulated in response to differing …

Aims: Sirtuins connect energy generation and metabolic stress to the cellular acetylome.
Currently, only the mitochondrial sirtuins (SIRT3–5) and SIRT1 have been shown to direct …