CX3CR1 is a chemokine receptor expressed on microglia that binds Fractalkine (CX3CL1)
and regulates microglial recruitment to sites of neuroinflammation. Full deletion of CX3CR1 …

Microglia, the primary immune effector cells in the brain, continually monitor the tissue
parenchyma for pathological alterations and become activated in Alzheimer's disease. Loss …

Chemokines are important modulators of neuroinflammation and neurodegeneration. In the
brains of Alzheimer's disease (AD) patients and in AD animal models, the chemokine …

In Alzheimer's disease (AD), amyloid-β (Aβ) deposits are frequently surrounded by activated
microglia but the precise role of these cells in disease progression remains unclear. The …

Background Despite its identification as a key checkpoint regulator of microglial activation in
Alzheimer's disease, the overarching role of CX3CR1 signaling in modulating mechanisms …

Several Alzheimer's disease (AD) risk genes are specifically expressed by microglia within
the CNS. However, the mechanisms by which microglia regulate the pathological hallmarks …

Aberrant microglial activation has been proposed to contribute to the cognitive decline in
Alzheimer disease (AD), but the underlying molecular mechanisms remain enigmatic …

Microglia and astrocytes are the major source of cytokines in Alzheimer, s disease (AD).
CX3CR1 is a delta chemokine receptor found in microglia and its neuronal ligand …

Circulating monocytoid cells have the ability to infiltrate nervous tissue, differentiate into
microglia, and clear amyloid-β (Aβ) from the brain of mouse models of Alzheimer's disease …

CX3CR1, one of the highest expressed genes in microglia in mice and humans, is
implicated in numerous microglial functions. However, the molecular mechanisms …