Oncogene-induced metabolic reprogramming is a hallmark of pancreatic cancer (PDAC), yet
the metabolic drivers of metastasis are unclear. In PDAC, obesity and excess fatty acids …

Cancer cells frequently display fundamentally altered cellular metabolism, which provides
the biochemical foundation and directly contributes to tumorigenicity and malignancy …

Bidirectional interactions between cancer cells and their microenvironment govern tumor
progression. Among the stromal cells in this microenvironment, adipocytes have been …

Experimental and molecular epidemiological studies indicate important roles for adipose
tissue or high-fat diet (HFD) in tumor growth and metastasis. Gastric cancer (GC) possesses …

The malignant progression of pancreatic ductal adenocarcinoma (PDAC) is accompanied by
a profound desmoplasia, which forces proliferating tumor cells to metabolically adapt to this …

Pancreatic ductal adenocarcinoma (PDAC) is projected to become the second deadliest
cancer by 2030, and the overall 5-year survival rate is currently less than 7%. Cancer cells …

Pancreatic cancer progression involves components of the tumor microenvironment,
including stellate cells, immune cells, endothelial cells, and the extracellular matrix …

Metastasis is the most malignant stage of cancer. Lipid metabolic abnormalities are now
increasingly recognized as characteristics of cancer cells. The accumulation of certain lipid …

While the distant organ environment is known to support metastasis of primary tumors, its
metabolic roles in this process remain underdetermined. Here, in breast cancer models, we …

Pancreatic cancer is one of the most serious health issues in developed and developing
countries, with a 5‐year overall survival rate currently< 9%. Patients typically present with …