Exosomes derived from Schwann cells ameliorate peripheral neuropathy in type 2 diabetic mice

L Wang, M Chopp, A Szalad, XR Lu, Y Zhang… - Diabetes, 2020 - Am Diabetes Assoc
Schwann cell–derived exosomes communicate with dorsal root ganglia (DRG) neurons. The
current study investigated the therapeutic effect of exosomes derived from healthy Schwann …

Mesenchymal stromal cell-derived exosomes ameliorate peripheral neuropathy in a mouse model of diabetes

B Fan, C Li, A Szalad, L Wang, W Pan, R Zhang… - Diabetologia, 2020 - Springer
Aims/hypothesis Diabetic peripheral neuropathy (DPN) is one of the major complications of
diabetes, which contributes greatly to morbidity and mortality. There is currently no effective …

[HTML][HTML] Exosomes derived from high-glucose–stimulated Schwann cells promote development of diabetic peripheral neuropathy

L Jia, M Chopp, L Wang, X Lu, A Szalad… - The FASEB …, 2018 - ncbi.nlm.nih.gov
Schwann cells actively interact with axons of dorsal root ganglia (DRG) neurons. Exosomes
mediate intercellular communication by transferring their biomaterials, including microRNAs …

Treatment of diabetic peripheral neuropathy with engineered mesenchymal stromal cell-derived exosomes enriched with microRNA-146a provide amplified …

B Fan, M Chopp, ZG Zhang, XS Liu - Experimental neurology, 2021 - Elsevier
Diabetic peripheral neuropathy (DPN) is one of the most prevalent chronic complications of
diabetes mellitus with no effective treatment. We recently demonstrated that mesenchymal …

Human mesenchymal stem cell derived exosomes alleviate type 2 diabetes mellitus by reversing peripheral insulin resistance and relieving β-cell destruction

Y Sun, H Shi, S Yin, C Ji, X Zhang, B Zhang, P Wu… - ACS …, 2018 - ACS Publications
Exosomes are nanosized extracellular vesicles (EVs) that show great promise in tissue
regeneration and injury repair as mesenchymal stem cell (MSC). MSC has been shown to …

[HTML][HTML] Transplantation of engineered exosomes derived from bone marrow mesenchymal stromal cells ameliorate diabetic peripheral neuropathy under electrical …

A Singh, A Raghav, PA Shiekh, A Kumar - Bioactive Materials, 2021 - Elsevier
Diabetic peripheral neuropathy (DPN) is a long-term complication associated with nerve
dysfunction and uncontrolled hyperglycemia. In spite of new drug discoveries, development …

Bone marrow-derived mesenchymal stem cells improve diabetes-induced cognitive impairment by exosome transfer into damaged neurons and astrocytes

M Nakano, K Nagaishi, N Konari, Y Saito, T Chikenji… - Scientific reports, 2016 - nature.com
The incidence of dementia is higher in diabetic patients, but no effective treatment has been
developed. This study showed that rat bone marrow mesenchymal stem cells (BM-MSCs) …

Exosomes from human adipose‐derived stem cells promote sciatic nerve regeneration via optimizing Schwann cell function

J Chen, S Ren, D Duscher, Y Kang… - Journal of Cellular …, 2019 - Wiley Online Library
Human adipose‐derived stem cells (ASCs) have a potential for the treatment of peripheral
nerve injury. Recent studies demonstrated that stem cells can mediate therapeutic effect by …

[HTML][HTML] Exosomes derived from differentiated human ADMSC with the Schwann cell phenotype modulate peripheral nerve-related cellular functions

B Liu, Y Kong, W Shi, M Kuss, K Liao, G Hu, P Xiao… - Bioactive materials, 2022 - Elsevier
Peripheral nerve regeneration remains a significant clinical challenge due to the
unsatisfactory functional recovery and public health burden. Exosomes, especially those …

Schwann cell-like differentiated adipose stem cells promote neurite outgrowth via secreted exosomes and RNA transfer

RC Ching, M Wiberg, PJ Kingham - Stem cell research & therapy, 2018 - Springer
Background Adipose derived stem cells can be stimulated to produce a growth factor rich
secretome which enhances axon regeneration. In this study we investigated the importance …