Newly identified loci that influence lipid concentrations and risk of coronary artery disease
To identify genetic variants influencing plasma lipid concentrations, we first used genotype
imputation and meta-analysis to combine three genome-wide scans totaling 8,816 …
imputation and meta-analysis to combine three genome-wide scans totaling 8,816 …
Common variants at 30 loci contribute to polygenic dyslipidemia
Blood low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol
and triglyceride levels are risk factors for cardiovascular disease. To dissect the polygenic …
and triglyceride levels are risk factors for cardiovascular disease. To dissect the polygenic …
Variants with large effects on blood lipids and the role of cholesterol and triglycerides in coronary disease
A Helgadottir, S Gretarsdottir, G Thorleifsson… - Nature …, 2016 - nature.com
Sequence variants affecting blood lipids and coronary artery disease (CAD) may enhance
understanding of the atherogenicity of lipid fractions. Using a large resource of whole …
understanding of the atherogenicity of lipid fractions. Using a large resource of whole …
Biological, clinical and population relevance of 95 loci for blood lipids
TM Teslovich, K Musunuru, AV Smith, AC Edmondson… - Nature, 2010 - nature.com
Plasma concentrations of total cholesterol, low-density lipoprotein cholesterol, high-density
lipoprotein cholesterol and triglycerides are among the most important risk factors for …
lipoprotein cholesterol and triglycerides are among the most important risk factors for …
Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans
S Kathiresan, O Melander, C Guiducci, A Surti… - Nature …, 2008 - nature.com
Blood concentrations of lipoproteins and lipids are heritable risk factors for cardiovascular
disease,. Using genome-wide association data from three studies (n= 8,816 that included …
disease,. Using genome-wide association data from three studies (n= 8,816 that included …
Discovery and refinement of loci associated with lipid levels
Nature genetics, 2013 - nature.com
Levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL)
cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for …
cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for …
Exome-wide association study of plasma lipids in> 300,000 individuals
We screened variants on an exome-focused genotyping array in> 300,000 participants
(replication in> 280,000 participants) and identified 444 independent variants in 250 loci …
(replication in> 280,000 participants) and identified 444 independent variants in 250 loci …
[HTML][HTML] Comprehensive genetic analysis of the human lipidome identifies loci associated with lipid homeostasis with links to coronary artery disease
We integrated lipidomics and genomics to unravel the genetic architecture of lipid
metabolism and identify genetic variants associated with lipid species putatively in the …
metabolism and identify genetic variants associated with lipid species putatively in the …
The power of genetic diversity in genome-wide association studies of lipids
Increased blood lipid levels are heritable risk factors of cardiovascular disease with varied
prevalence worldwide owing to different dietary patterns and medication use. Despite …
prevalence worldwide owing to different dietary patterns and medication use. Despite …
[HTML][HTML] Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts
Recent genome-wide association (GWA) studies of lipids have been conducted in samples
ascertained for other phenotypes, particularly diabetes. Here we report the first GWA …
ascertained for other phenotypes, particularly diabetes. Here we report the first GWA …