Recent studies indicate that glucose metabolism is altered in rheumatoid arthritis. We
hypothesize that Pkm2, as a key regulatory enzyme of glycolysis pathway, triggers the …

Immunometabolism provides a new perspective on the pathogenesis of rheumatoid arthritis
(RA). In recent years, there have been investigations focusing on the role of intracellular …

Objectives Expansion of follicular helper T (Tfh) cells and abnormal glucose metabolism are
present in patients with systemic lupus erythematosus (SLE). Pyruvate kinase M2 (PKM2) is …

Background Some studies have indicated that glucose metabolism plays an important role
in the pathogenesis of rheumatoid arthritis (RA). This study aimed to find the novel genes …

Emerging evidence suggests that metabolic adaptation is a vital hallmark and prerequisite
for macrophage phenotype transition. Pyruvate kinase M2 (PKM2) is an essential molecular …

Macrophages play a critical role in ankylosing spondylitis by promoting autoimmune tissue
inflammation through various effector functions. The inflammatory potential of macrophages …

Th17 cell differentiation and pathogenicity depend on metabolic reprogramming inducing
shifts toward glycolysis. Here, we show that the pyruvate kinase M2 (PKM2), a glycolytic …

Pyruvate kinase M2 (PKM2) has been wildly verified to modulate glycolysis in tumor cells.
However, the role of PKM2 on the glycolysis of osteoarthritis (OA) chondrocytes is still …

Objective This study aimed to evaluate glycolysis inhibitor which can effectively ameliorate
arthritis by inhibiting synoviocyte activation through AMPK/NF-кB pathway in AA rats …

Pyruvate kinase (PK) is a key enzyme that catalyzes the dephosphorylation of
phosphoenolpyruvate (PEP) into pyruvate, and is responsible for the production of ATP …