Abstract Background Public Health England has recommended that services be put in place
to support people who choose to withdraw from antidepressants because of a current gap …

Background Several long‐term double‐blind placebo controlled trials have shown
prophylactic antidepressant therapy in unipolar depression. The goal of this work was to …

Rationale Premature discontinuation of antidepressant drugs is a frequent clinical problem.
Adverse effects are common, occur early on in treatment and are reported to be one of the …

Background: Understanding patients' ambivalence about treatment persistence may be
useful in tailoring retention interventions for individual patients with major depressive …

The good news is that advances in the treatment of depression in the past decade have led
to better recognition of those with depression, and also to a reduction in the number of …

Background: Anecdotal reports concerning mood disorder patients suggest restarting drug
treatment in patients who prematurely discontinue it may be associated with a diminished …

As descriptors for the clinical course and treatment of depressive illness, terms such as
response, remission, and recovery have evolved with our understanding of the disease, yet …

Background: Hypomania or mania have rarely been reported to develop shortly after the
discontinuation of an antidepressant drug. The true incidence of this discontinuation …

OBJECTIVE: The primary objective of this article is to review the literature regarding the
speed of response to antidepressant drugs and potential strategies to accelerate the …

The abrupt discontinuation of antidepressants can result in a syndrome of adverse events,
including somatic, mood and psychomotor reactions. This study examined the effects of …