Acute renal ischemia is an infrequently encountered clinical entity with occasionally
devastating consequences. The renal compensation to acute ischemia is unknown and is …

Acute kidney injury (AKI) is a significant clinical problem associated with poor outcome. The
kidney, due to its inhomogeneous blood flow, is particularly susceptible to changes in …

Ischemic nephropathy describes progressive renal failure, defined by significantly reduced
glomerular filtration rate, and may be due to renal artery stenosis (RAS), a narrowing of the …

Objectives: Acute kidney injury occurs frequently after cardiac or major vascular surgery and
is believed to be predominantly a consequence of impaired renal oxygenation. However, in …

The isolated perfused rat kidney was used to characterize the renal response to hypoxia
while flow was maintained. Hypoxia resulted in an 85% reduction in glomerular filtration rate …

Abstract Models of ischemic acute renal failure (ARF) must consider the combination of
tissue hypoxia, insufficient nutrient flow, and anaerobic waste product accumulation. This …

Tissue hypoxia has been demonstrated, in both the renal cortex and medulla, during the
acute phase of reperfusion after ischemia induced by occlusion of the aorta upstream from …

Tissue hypoxia has been proposed as an important event in renal ischemia-reperfusion
injury (IRI), particularly during the period of ischemia and in the immediate hours following …

We examined the mechanisms that maintain stable renal tissue Po2 during moderate renal
ischemia, when changes in renal oxygen delivery (Ḋo2) and consumption (V̇o2) are …

Ischemia is the most common cause of acute renal failure. Ischemic-induced renal tissue
hypoxia is thought to be a major component in the development of acute renal failure in …