Microglia as a source and target of cytokines

UK Hanisch - Glia, 2002 - Wiley Online Library
Cytokines constitute a significant portion of the immuno‐and neuromodulatory messengers
that can be released by activated microglia. By virtue of potent effects on resident and …

Microglia biology in health and disease

GA Garden, T Möller - Journal of Neuroimmune Pharmacology, 2006 - Springer
Microglia cells are resident central nervous system (CNS) leukocytes that regulate innate
immunity and participate in adaptive immune responses in CNS tissue. However, microglia …

Neurotransmitter receptors on microglia

JM Pocock, H Kettenmann - Trends in neurosciences, 2007 - cell.com
Microglia are the intrinsic immune cells of the brain and express chemokine and cytokine
receptors that interact with the peripheral immune cells. Recent studies have indicated that …

Role of microglia in neurological disorders and their potentials as a therapeutic target

L Du, Y Zhang, Y Chen, J Zhu, Y Yang… - Molecular neurobiology, 2017 - Springer
Microglia are resident macrophage-like immune cells in the central nervous system (CNS)
and play a vital role in both physiological and pathological conditions, including restoring …

Microglia: key innate immune cells of the brain

J Kofler, CA Wiley - Toxicologic pathology, 2011 - journals.sagepub.com
Microglia are the histiocytes of the central nervous system. These long-lived cells undergo
very little turnover in normal physiological states; however, in pathological conditions …

Microglial physiology: unique stimuli, specialized responses

RM Ransohoff, VH Perry - Annual review of immunology, 2009 - annualreviews.org
Microglia, the macrophages of the central nervous system parenchyma, have in the normal
healthy brain a distinct phenotype induced by molecules expressed on or secreted by …

Physiology of microglia

H Kettenmann, UK Hanisch, M Noda… - Physiological …, 2011 - journals.physiology.org
Microglial cells are the resident macrophages in the central nervous system. These cells of
mesodermal/mesenchymal origin migrate into all regions of the central nervous system …

Microglia

D van Rossum, UK Hanisch - Metabolic brain disease, 2004 - Springer
Microglia—the macrophage equivalent of the CNS—safeguards and supports neuronal
functions. Threats to the CNS homeostasis can trigger a rapid transformation of these cells …

[HTML][HTML] Microglia: a sensor for pathological events in the CNS

GW Kreutzberg - Trends in neurosciences, 1996 - cell.com
The most characteristic feature of microglial cells is their rapid activation in response to even
minor pathological changes in the CNS. Microglia activation is a key factor in the defence of …

Role of microglia in neuronal degeneration and regeneration

L Walter, H Neumann - Seminars in immunopathology, 2009 - Springer
Microglial cells, the resident macrophage population of the central nervous system (CNS),
actively scan tissue under both normal and pathologic contexts. Their resulting engagement …