Low-molecular-weight constituents of isolated insulin-secretory granules. Bivalent cations, adenine nucleotides and inorganic phosphate
JC Hutton, EJ Penn, M Peshavaria - Biochemical Journal, 1983 - portlandpress.com
The concentrations of Zn2+, Ca2+, Mg2+, Pi and adenine nucleotides were determined in
insulin-secretory granules prepared from a transplantable rat insulinoma. Differential and …
insulin-secretory granules prepared from a transplantable rat insulinoma. Differential and …
Physicochemical characteristics of insulin secretion granules
HG Coore, B Hellman, E Pihl, IB Täljedal - Biochemical Journal, 1969 - portlandpress.com
β-Granules were prepared from micro-dissected pancreatic islets of obese–hyperglycaemic
mice. This fraction contained 60% of the insulin, 30% of the cytochrome oxidase, 16% of the …
mice. This fraction contained 60% of the insulin, 30% of the cytochrome oxidase, 16% of the …
ISOLATION AND PROPERTIES OF SECRETORY GRANULES FROM RAT ISLETS OF LANGERHANS: III. Studies of the Stability of the Isolated Beta Granules
SL Howell, DA Young, PE Lacy - The Journal of Cell Biology, 1969 - rupress.org
A partially purified secretory granule fraction, isolated from rat islets of Langerhans by
differential centrifugation, was used for investigating the stability of the beta granules during …
differential centrifugation, was used for investigating the stability of the beta granules during …
The internal pH and membrane potential of the insulin-secretory granule
JC Hutton - Biochemical Journal, 1982 - portlandpress.com
The membrane potential (ΔΨ) and the pH gradient (ΔpH) across the membrane of the
insulin-secretory granule were determined in studies in vitro from the uptake of the permeant …
insulin-secretory granule were determined in studies in vitro from the uptake of the permeant …
[HTML][HTML] Studies on the molecular organization of rat insulin secretory granules.
J Michael, R Carroll, HH Swift, DF Steiner - Journal of Biological Chemistry, 1987 - Elsevier
Secretory granule-enriched fractions prepared from isolated rat islets of Langerhans,
previously labeled in culture for 18 h with [3H] leucine, have been lysed and separated into …
previously labeled in culture for 18 h with [3H] leucine, have been lysed and separated into …
Isolation and characterisation of insulin secretory granules from a rat islet cell tumour
JC Hutton, EJ Penn, M Peshavaria - Diabetologia, 1982 - Springer
Density gradient centrifugation techniques, using iso-osmotic colloidal silica suspensions
(Percoll), were developed for the isolation of insulin secretory granules from a transplantable …
(Percoll), were developed for the isolation of insulin secretory granules from a transplantable …
Elemental composition of secretory granules in pancreatic islets of Langerhans
MC Foster, RD Leapman, MX Li, I Atwater - Biophysical journal, 1993 - cell.com
We have characterized, by electron probe microanalysis, rapidly frozen cultured rat islets at
the level of individual secretory granules. Elemental analysis of thin, dried cryosections …
the level of individual secretory granules. Elemental analysis of thin, dried cryosections …
[引用][C] Hypothesis: single and chain release of insulin secretory granules is related to anionic transport at exocytotic sites
L Orci, W Malaisse - Diabetes, 1980 - Am Diabetes Assoc
The release of insulin evoked by nutrient secreta-gogues (eg, glucose) in the pancreatic B-
cell is mediated by a sequence of metabolic, ionic, and motile events, culminating in the …
cell is mediated by a sequence of metabolic, ionic, and motile events, culminating in the …
Newcomer insulin secretory granules as a highly calcium-sensitive pool
MG Pedersen, A Sherman - Proceedings of the National …, 2009 - National Acad Sciences
Insulin secretion is biphasic in response to a step in glucose stimulation. Recent
experiments suggest that 2 different mechanisms operate during the 2 phases, with transient …
experiments suggest that 2 different mechanisms operate during the 2 phases, with transient …
An in Vitro system for studying insulin release caused by secretory granules‐plasma membrane interaction: definition of the system.
B Davis, NR Lazarus - The Journal of Physiology, 1976 - Wiley Online Library
1. An in vitro system is described in which insulin beta‐granule‐plasma membrane
interaction can be studied. 2. The system shows an absolute requirement for physiological …
interaction can be studied. 2. The system shows an absolute requirement for physiological …
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