A Common LPA Null Allele Associates With Lower Lipoprotein(a) Levels and Coronary Artery Disease Risk

T Kyriakou, U Seedorf, A Goel… - … , and vascular biology, 2014 - Am Heart Assoc
Objective—Increased levels of lipoprotein (a) are a highly heritable risk factor for coronary
artery disease (CAD). The genetic determinants of lipoprotein (a) levels are mainly because …

Validation and quantification of genetic determinants of lipoprotein-a levels and predictive value for angiographic coronary artery disease

JL Anderson, S Knight, HT May, BD Horne… - The American Journal of …, 2013 - Elsevier
Lipoprotein (a)(Lp [a]) has gained attention as a heritable coronary artery disease (CAD) risk
factor and therapeutic target. Two genetic variants in the LPA gene have been reported to …

Genome-Wide Association Study and Identification of a Protective Missense Variant on Lipoprotein (a) Concentration: Protective Missense Variant on Lipoprotein (a) …

MA Said, MW Yeung, YJ van de Vegte… - … , and vascular biology, 2021 - Am Heart Assoc
Objective: Lipoprotein (a)(Lp [a]) is associated with coronary artery disease (CAD) but also
to LDL (low-density lipoprotein) cholesterol. The genetic architecture of Lp (a) remains …

Genetics of plasma lipoprotein (a) concentrations

E Boerwinkle - Current Opinion in Lipidology, 1992 - journals.lww.com
Abstract Lipoprotein (a)[Lp (a)] is a low-density-like lipoprotein with the addition of a Lp (a)-
specific protein, apolipoprotein (a)[apo (a)]. Plasma concentrations of Lp (a) are a risk factor …

Lipoprotein (a) as a potential causal genetic risk factor of cardiovascular disease: a rationale for increased efforts to understand its pathophysiology and develop …

S Tsimikas, JL Hall - Journal of the American College of Cardiology, 2012 - jacc.org
Recent published studies have provided increasing evidence that lipoprotein (a)[Lp (a)] may
be a potential causal, genetic, independent risk factor for cardiovascular disease (CVD). Lp …

Apolipoprotein (a) genetic sequence variants associated with systemic atherosclerosis and coronary atherosclerotic burden but not with venous thromboembolism

A Helgadottir, S Gretarsdottir, G Thorleifsson… - Journal of the American …, 2012 - jacc.org
Objectives: The purpose of this study is investigate the effects of variants in the
apolipoprotein (a) gene (LPA) on vascular diseases with different atherosclerotic and …

Association of polymorphisms of the apolipoprotein (a) gene with lipoprotein (a) levels and myocardial infarction

SR Holmer, C Hengstenberg, HG Kraft, B Mayer… - Circulation, 2003 - Am Heart Assoc
Background—Serum lipoprotein (a)[Lp (a)] concentration is largely determined by variability
at the apolipoprotein (a) gene locus. Most prominent effects relate to polymorphisms in the …

Lipoprotein (a): genotype–phenotype relationship and impact on atherogenic risk

B Enkhmaa, E Anuurad, W Zhang, T Tran… - … syndrome and related …, 2011 - liebertpub.com
In 2010, more than 45 years after the initial discovery of lipoprotein (a)[Lp (a)] by Kare Berg,
an European Atherosclerosis Society Consensus Panel recommended screening for …

A polymorphism in the protease-like domain of apolipoprotein (a) is associated with severe coronary artery disease

MM Luke, JP Kane, DM Liu, CM Rowland… - … , and vascular biology, 2007 - Am Heart Assoc
Objectives—The purpose of this study was to identify genetic variants associated with
severe coronary artery disease (CAD). Methods and Results—We used 3 case-control …

Genetic variants in the apolipoprotein (a) gene and coronary heart disease

Y Li, MM Luke, D Shiffman, JJ Devlin - Circulation: Cardiovascular …, 2011 - Am Heart Assoc
Two independent single-nucleotide polymorphisms (SNPs) in the gene encoding
apolipoprotein (a)(LPA) have been shown to be associated with coronary heart disease …