Lipoprotein (a) and apolipoprotein (a) isoform size: associations with angiographic extent and severity of coronary artery disease, and carotid artery plaque

EMM Ooi, KL Ellis, PHR Barrett, GF Watts, J Hung… - Atherosclerosis, 2018 - Elsevier
Background and aims Lipoprotein (a)[Lp (a)] is an emerging genetic risk factor for
cardiovascular disease (CVD). We examined whether plasma Lp (a) concentration and …

Lipoprotein (a) and long-term cardiovascular risk in a multi-ethnic pooled prospective cohort

ND Wong, W Fan, X Hu, C Ballantyne… - Journal of the American …, 2024 - jacc.org
Abstract Background Lipoprotein (a)(Lp [a]) is a causal genetic risk factor for atherosclerotic
cardiovascular disease (ASCVD). There are limited long-term follow-up data from large US …

Lipoprotein (a) an elusive cardiovascular risk factor

L Berglund, R Ramakrishnan - Arteriosclerosis, thrombosis, and …, 2004 - Am Heart Assoc
Lipoprotein (a)[Lp (a)], is present only in humans, Old World nonhuman primates, and the
European hedgehog. Lp (a) has many properties in common with low-density lipoprotein …

Lipoprotein (a) and ischemic heart disease—a causal association? A review

PR Kamstrup - Atherosclerosis, 2010 - Elsevier
The aim of this review is to summarize present evidence of a causal association of
lipoprotein (a) with risk of ischemic heart disease (IHD). Evidence for causality includes …

Polymorphism in the apolipoprotein (a) gene, plasma lipoprotein (a), cardiovascular disease, and low-dose aspirin therapy

DI Chasman, D Shiffman, RYL Zee, JZ Louie, MM Luke… - Atherosclerosis, 2009 - Elsevier
OBJECTIVE: A minor allele variant (rs3798220) of apolipoprotein (a) has been reported to
be associated with elevated plasma lipoprotein (a)[Lp (a)] and increased cardiovascular risk …

LPA genotype is associated with premature cardiovascular disease in familial hypercholesterolemia

M Paquette, S Bernard, G Thanassoulis… - Journal of Clinical …, 2019 - Elsevier
Background In recent years, lipoprotein (a)(Lp (a)) has been recognized as an important risk
factor for cardiovascular disease (CVD). A variant in the LPA gene, rs10455872, has been …

Phenotypic characterization of genetically lowered human lipoprotein (a) levels

CA Emdin, AV Khera, P Natarajan, D Klarin… - Journal of the American …, 2016 - jacc.org
Background: Genomic analyses have suggested that the LPA gene and its associated
plasma biomarker, lipoprotein (a)(Lp [a]), represent a causal risk factor for coronary heart …

Lipoprotein (a) concentrations, apolipoprotein (a) phenotypes, and peripheral arterial disease in three independent cohorts

A Laschkolnig, B Kollerits, C Lamina… - Cardiovascular …, 2014 - academic.oup.com
Aims The relevance of lipoprotein (a)[Lp (a)] concentrations and low-molecular-weight
(LMW) apo (a) phenotypes in peripheral arterial disease (PAD) has only been investigated …

Structure, function, and genetics of lipoprotein (a)

K Schmidt, A Noureen, F Kronenberg… - Journal of lipid …, 2016 - ASBMB
Lipoprotein (a)[Lp (a)] has attracted the interest of researchers and physicians due to its
intriguing properties, including an intragenic multiallelic copy number variation in the LPA …

Lipoprotein (a): a genetically determined, causal, and prevalent risk factor for atherosclerotic cardiovascular disease: a scientific statement from the American Heart …

G Reyes-Soffer, HN Ginsberg, L Berglund… - … , and vascular biology, 2022 - Am Heart Assoc
High levels of lipoprotein (a)[Lp (a)], an apoB100-containing lipoprotein, are an independent
and causal risk factor for atherosclerotic cardiovascular diseases through mechanisms …