Lipoprotein (a): a genetic risk factor for premature coronary heart disease

AM Scanu - JAMA, 1992 - jamanetwork.com
Lipoprotein (a)(Lp [a]) can be defined as a lipoprotein particle having as a protein moiety
apolipoprotein B-100 (the protein associated with low-density lipoprotein) disulfide-linked to …

New horizons: revival of lipoprotein (a) as a risk factor for cardiovascular disease

P Nestel, WJ Loh, NC Ward… - The Journal of Clinical …, 2022 - academic.oup.com
The status of lipoprotein (a)[Lp (a)] as a cardiovascular risk factor has been resurrected by
advances in genetics. Mendelian randomization studies show a causal link of Lp (a) with …

Association of Lipoprotein (a) variants with risk of cardiovascular disease: a Mendelian randomization study

J Xia, C Guo, K Liu, Y Xie, H Cao, W Peng… - Lipids in Health and …, 2021 - Springer
Background There is a well-documented empirical relationship between lipoprotein (a)[Lp
(a)] and cardiovascular disease (CVD); however, causal evidence, especially from the …

Lipoprotein (a): a genetic marker for cardiovascular disease and target for emerging therapies

A Cesaro, A Schiavo, E Moscarella… - Journal of …, 2021 - journals.lww.com
Abstract Lipoprotein (a)[Lp (a)] is an established cardiovascular risk factor, and growing
evidence indicates its causal association with atherosclerotic disease because of the …

Lipoprotein (a), atherosclerosis, and apolipoprotein (a) gene polymorphism

U Pati, N Pati - Molecular Genetics and Metabolism, 2000 - Elsevier
High plasma lipoprotein (a)[Lp (a)] levels have been implicated as an independent risk
factor for coronary artery disease in Caucasians, Chinese, Africans, and Indians. Apo (a) that …

Lipoprotein (a) levels and the risk of myocardial infarction among 7 ethnic groups

G Paré, A Çaku, M McQueen, SS Anand, E Enas… - Circulation, 2019 - Am Heart Assoc
Background: Lipoprotein (a)[Lp (a)] levels predict the risk of myocardial infarction (MI) in
populations of European ancestry; however, few data are available for other ethnic groups …

Contribution of Lipoprotein (a) to Polygenic Risk Prediction of Coronary Artery Disease: A Prospective UK Biobank Analysis

HD Manikpurage, A Paulin, A Girard… - Circulation: Genomic …, 2023 - Am Heart Assoc
Background: Lp (a)(lipoprotein [a]) is a highly atherogenic lipoprotein subfraction that may
contribute to polygenic risk of coronary artery disease (CAD), but the extent of this …

[HTML][HTML] Lipoprotein (a) beyond the kringle IV repeat polymorphism: the complexity of genetic variation in the LPA gene

S Coassin, F Kronenberg - Atherosclerosis, 2022 - Elsevier
Abstract High lipoprotein (a)[Lp (a)] concentrations are one of the most important genetically
determined risk factors for cardiovascular disease. Lp (a) concentrations are an enigmatic …

Lipoprotein (a) in health and disease

F Kronenberg, A Steinmetz, GM Kostner… - Critical reviews in …, 1996 - Taylor & Francis
Abstract Lipoprotein (a)[Lp (a)] represents an LDL-like particle to which the Lp (a)-specific
apolipoprotein (a) is linked via a disulfide bridge. It has gained considerable interest as a …

Lipoprotein (a) concentration, genetic variants, apo (a) isoform size, and cellular cholesterol efflux in patients with elevated Lp (a) and coronary heart disease …

C Stefanutti, L Pisciotta, E Favari, S Di Giacomo… - Journal of Clinical …, 2020 - Elsevier
Background Coronary artery disease (CAD) risk is greater with higher plasma lipoprotein
(a)[Lp (a)] concentrations or smaller apoisoform size and putatively with increased cellular …