[HTML][HTML] An overview of mammalian p38 mitogen-activated protein kinases, central regulators of cell stress and receptor signaling

J Han, J Wu, J Silke - F1000Research, 2020 - ncbi.nlm.nih.gov
The p38 family is a highly evolutionarily conserved group of mitogen-activated protein
kinases (MAPKs) that is involved in and helps co-ordinate cellular responses to nearly all …

Activation and signaling of the p38 MAP kinase pathway

T Zarubin, J Han - Cell research, 2005 - nature.com
The family members of the mitogen-activated protein (MAP) kinases mediate a wide variety
of cellular behaviors in response to extracellular stimuli. One of the four main sub-groups …

Diversity and versatility of p38 kinase signalling in health and disease

B Canovas, AR Nebreda - Nature reviews Molecular cell biology, 2021 - nature.com
The ability of cells to deal with different types of stressful situations in a precise and
coordinated manner is key for survival and involves various signalling networks. Over the …

The p38 signal transduction pathway activation and function

K Ono, J Han - Cellular signalling, 2000 - Elsevier
The p38 signalling transduction pathway, a Mitogen-activated protein (MAP) kinase
pathway, plays an essential role in regulating many cellular processes including …

p38 MAP kinases: key signalling molecules as therapeutic targets for inflammatory diseases

S Kumar, J Boehm, JC Lee - Nature reviews Drug discovery, 2003 - nature.com
The p38 MAP kinases are a family of serine/threonine protein kinases that play important
roles in cellular responses to external stress signals. Since their identification about 10 years …

New insights into the p38γ and p38δ MAPK pathways

A Risco, A Cuenda - Journal of signal transduction, 2012 - Wiley Online Library
The mammalian p38 mitogen‐activated protein kinases (MAPKs) family is composed of four
members (p38α, p38β, p38γ, and p38δ), which are very similar in amino acid sequence but …

p38MAPK: stress responses from molecular mechanisms to therapeutics

LR Coulthard, DE White, DL Jones… - Trends in molecular …, 2009 - cell.com
The p38 MAPK protein kinases affect a variety of intracellular responses, with well-
recognized roles in inflammation, cell-cycle regulation, cell death, development …

p38 MAP kinases in the heart

T Yokota, Y Wang - Gene, 2016 - Elsevier
Abstract p38 kinases are members of the mitogen-activated protein kinases (MAPK) with
established contribution to a wide range of signaling pathways and different biological …

Mechanisms and functions of p38 MAPK signalling

A Cuadrado, AR Nebreda - Biochemical journal, 2010 - portlandpress.com
The p38 MAPK (mitogen-activated protein kinase) signalling pathway allows cells to
interpret a wide range of external signals and respond appropriately by generating a …

Atypical p38 signaling, activation, and implications for disease

JC Burton, W Antoniades, J Okalova, MM Roos… - International Journal of …, 2021 - mdpi.com
The mitogen-activated protein kinase (MAPK) p38 is an essential family of kinases,
regulating responses to environmental stress and inflammation. There is an ever-increasing …