[HTML][HTML] Cell competition and the regulation of protein homeostasis

S Krishnan, PK Paul, TA Rodriguez - Current Opinion in Cell Biology, 2024 - Elsevier
The process of embryonic development involves remarkable cellular plasticity, which
governs the coordination between cells necessary to build an organism. One role of this …

[PDF][PDF] Differences in mitochondrial activity trigger cell competition during early mouse development

A Lima, G Lubatti, J Burgstaller, D Hu, A Green… - bioRxiv, 2020 - researchgate.net
Cell competition is emerging as a quality control mechanism that eliminates unfit cells in a
wide range of settings from development to the adult. However, the nature of the cells …

Cell competition acts as a purifying selection to eliminate cells with mitochondrial defects during early mouse development

A Lima, G Lubatti, J Burgstaller, D Hu, AP Green… - Nature …, 2021 - nature.com
Cell competition is emerging as a quality-control mechanism that eliminates unfit cells in a
wide range of settings from development to the adult. However, the nature of the cells …

Cell competition in vertebrates—A key machinery for tissue homeostasis

T Maruyama, Y Fujita - Current Opinion in Genetics & Development, 2022 - Elsevier
Cell competition is a process by which cells with different properties compete with each
other for survival and space, and consequently suboptimal/abnormal cells are often …

Cell competition: how to eliminate your neighbours

M Amoyel, EA Bach - Development, 2014 - journals.biologists.com
A conventional view of development is that cells cooperate to build an organism. However,
based on studies of Drosophila, it has been known for years that viable cells can be …

Cell competition in development: information from flies and vertebrates

E Madan, R Gogna, E Moreno - Current opinion in cell biology, 2018 - Elsevier
Cell competition is a biological mechanism conserved from Drosophila to vertebrates
wherein neighboring cells compare their relative fitness status resulting in the elimination of …

Mechanisms of cell competition: themes and variations

R Levayer, E Moreno - Journal of cell biology, 2013 - rupress.org
Cell competition is the short-range elimination of slow-dividing cells through apoptosis when
confronted with a faster growing population. It is based on the comparison of relative cell …

Cell wars: regulation of cell survival and proliferation by cell competition

S Vivarelli, L Wagstaff, E Piddini - Essays in biochemistry, 2012 - portlandpress.com
During cell competition fitter cells take over the tissue at the expense of viable, but less fit,
cells, which are eliminated by induction of apoptosis or senescence. This probably acts as a …

Evolution and cell physiology. 2. The evolution of cell signaling: from mitochondria to Metazoa

NW Blackstone - American Journal of Physiology-Cell …, 2013 - journals.physiology.org
The history of life is a history of levels-of-selection transitions. Each transition requires
mechanisms that mediate conflict among the lower-level units. In the origins of multicellular …

Cell competition: emerging signaling and unsolved questions

R Nagata, T Igaki - FEBS letters, 2024 - Wiley Online Library
Multicellular communities have an intrinsic mechanism that optimizes their structure and
function via cell–cell communication. One of the driving forces for such self‐organization of …