Stress signaling and cellular proliferation reverse the effects of mitochondrial mistranslation

N Ferreira, KL Perks, G Rossetti, DL Rudler… - The EMBO …, 2019 - embopress.org
Translation fidelity is crucial for prokaryotes and eukaryotic nuclear‐encoded proteins;
however, little is known about the role of mistranslation in mitochondria and its potential …

[HTML][HTML] Cell competition: A historical perspective

G Morata - Developmental Biology, 2021 - Elsevier
Cell competition is a homeostatic process designed to remove from animal tissues viable
cells that are unfit, abnormal or malignant and that may compromise the general fitness or …

Survival of the fittest: essential roles of cell competition in development, aging, and cancer

MM Merino, R Levayer, E Moreno - Trends in cell biology, 2016 - cell.com
Multicellular organisms evolved to resolve conflicts between individual cells, protecting the
internal organization of the individual. This is illustrated by cell competition, a process that …

Cell competition: Emerging mechanisms to eliminate neighbors

R Nagata, T Igaki - Development, growth & differentiation, 2018 - Wiley Online Library
Cell competition is a context‐dependent cell elimination through short‐range cell–cell
interaction, in which cells with higher fitness eliminate neighboring less‐fit or oncogenic …

Proteotoxic stress is a driver of the loser status and cell competition

ME Baumgartner, MP Dinan, PF Langton… - Nature Cell …, 2021 - nature.com
Cell competition allows winner cells to eliminate less fit loser cells in tissues. In Minute cell
competition, cells with a heterozygous mutation in ribosome genes, such as RpS3+/− cells …

The competitive nature of cells

B Díaz, E Moreno - Experimental cell research, 2005 - Elsevier
The possibility that cells of multicellular organisms may compete with one another has been
postulated several times. It was experimentally confirmed in Drosophila, probably for the first …

[HTML][HTML] Mitochondria lead the way: mitochondrial dynamics and function in cellular movements in development and disease

S Madan, B Uttekar, S Chowdhary… - Frontiers in Cell and …, 2022 - frontiersin.org
The dynamics, distribution and activity of subcellular organelles are integral to regulating
cell shape changes during various physiological processes such as epithelial cell formation …

Picking winners and losers: cell competition in tissue development and homeostasis

W Kim, R Jain - Trends in Genetics, 2020 - cell.com
Viable cells with reduced fitness are often eliminated by neighboring cells with greater
fitness. This phenomenon, called cell competition, is an important mechanism for …

Why do cells need oxygen? Insights from mitochondrial composition and function

KM Manoj, DA Gideon, L Jaeken - Cell Biology International, 2022 - Wiley Online Library
Mitochondrial membrane‐embedded redox proteins are classically perceived as
deterministic “electron transport chain”(ETC) arrays cum proton pumps; and oxygen is seen …

Mitochondrial metabolism and the continuing search for ultimate regulators of developmental rate

M Diaz-Cuadros - Current Opinion in Genetics & Development, 2024 - Elsevier
Highlights•The speed of gene expression steps correlates with the rate of embryonic
development.•Mitochondrial metabolism may give rise to species-specific gene expression …