To maintain homeostasis, every cell must constantly monitor its energy level and
appropriately adjust energy, in the form of ATP, production rates based on metabolic …

Yeast cell factories encounter physical and chemical stresses when used for industrial
production of fuels and chemicals. These stresses reduce productivity and increase …

Since its inception, cellular plasticity has undergone many iterations. Today we define it as
the ability of mature, terminally differentiated cells to change their identity, meaning lineage …

Highlights•Mature differentiated cells can dedifferentiate or transdifferentiate.•Plasticity can
be experimentally induced, but also occurs physiologically.•Dedifferentiation occurs to …

A member of the USSR Academy of Sciences shares his model of how cells recover {rom
blows to their protein-making machinery organism whose cells cannot make protein is …

The mechanisms by which cells adapt to proteotoxic stress are largely unknown, but are key
to understanding how tumor cells, particularly in vivo, are largely resistant to proteasome …

Highlights•Mitochondrial-mediated signaling regulates the fate of stem cells.•Activation of
mitochondrial OXPHOS is an upstream mechanism in the differentiation …

Regeneration requires related cells to diverge in fate. We show that activated lymphocytes
yield sibling cells with unequal elimination of aged mitochondria. Disparate mitochondrial …

Mitochondria are essential for normal cellular function and have emerged as key aging
determinants. Indeed, defects in mitochondrial function have been linked to cardiovascular …

The evolutionary acquisition of mitochondria has given rise to the diversity of eukaryotic life.
Mitochondria have retained their ancestral α‐proteobacterial traits through the maintenance …