Mitophagy and quality control mechanisms in mitochondrial maintenance

S Pickles, P Vigié, RJ Youle - Current Biology, 2018 - cell.com
The maintenance of a healthy and functional mitochondrial network is critical during
development as well as throughout life in the response to physiological adaptations and …

Cell competition in vertebrate organ size regulation

AI Penzo‐Méndez, BZ Stanger - Wiley Interdisciplinary Reviews …, 2014 - Wiley Online Library
The study of animal organ size determination has provided evidence of the existence of
organ‐intrinsic mechanisms that 'sense'and adjust organ growth. Cell competition, a form of …

[HTML][HTML] Staying cool in difficult times: mitochondrial dynamics, quality control and the stress response

TE Shutt, HM McBride - Biochimica et Biophysica Acta (BBA)-Molecular …, 2013 - Elsevier
One of the critical problems with the combustion of sugar and fat is the generation of cellular
oxidation. The ongoing consumption of oxygen results in damage to lipids, protein and …

Chatty mitochondria: keeping balance in cellular protein homeostasis

U Topf, L Wrobel, A Chacinska - Trends in cell biology, 2016 - cell.com
Mitochondria are multifunctional cellular organelles that host many biochemical pathways
including oxidative phosphorylation (OXPHOS). Defective mitochondria pose a threat to …

Mitochondrial respiratory quiescence: A new model for examining the role of mitochondrial metabolism in development

H Hocaoglu, M Sieber - Seminars in cell & developmental biology, 2023 - Elsevier
Mitochondria are vital organelles with a central role in all aspects of cellular metabolism. As
a means to support the ever-changing demands of the cell, mitochondria produce energy …

Mitochondrial protein-induced stress triggers a global adaptive transcriptional programme

F Boos, L Krämer, C Groh, F Jung, P Haberkant… - Nature cell …, 2019 - nature.com
The cytosolic accumulation of mitochondrial precursors is hazardous to cellular fitness and
is associated with a number of diseases. However, it is not observed under physiological …

Mechanisms of mitochondrial respiratory adaptation

CF Bennett, P Latorre-Muro, P Puigserver - Nature Reviews Molecular …, 2022 - nature.com
Mitochondrial energetic adaptations encompass a plethora of conserved processes that
maintain cell and organismal fitness and survival in the changing environment by adjusting …

Molecular machinery and pathophysiology of mitochondrial dynamics

YH Chiu, SCA Lin, CH Kuo, CJ Li - Frontiers in Cell and …, 2021 - frontiersin.org
Mitochondria are double-membraned organelles that exhibit fluidity. They are the main site
of cellular aerobic respiration, providing energy for cell proliferation, migration, and survival; …

Systemic effects of mitochondrial stress

R Bar‐Ziv, T Bolas, A Dillin - EMBO reports, 2020 - embopress.org
Multicellular organisms are complex biological systems, composed of specialized tissues
that require coordination of the metabolic and fitness state of each component. In the cells …

Mitochondrial control of cell fate

G Gong, H Zhang, SC Kolwicz Jr - Frontiers in Cell and …, 2023 - frontiersin.org
Mitochondria play a critical role in cells, not only through the regeneration of ATP, but via
other cellular processes including calcium hemostasis, redox, and apoptosis (Li et al., 2022) …