Cellular proteostasis is maintained via the coordinated synthesis, maintenance, and
breakdown of proteins in the cytosol and organelles. While biogenesis of the mitochondrial …

Mitochondria have long been appreciated as the metabolic hub of cells. Emerging evidence
also posits these organelles as hubs for innate immune signalling and activation, particularly …

The regulated clearance of mitochondria is a well recognized but poorly understood aspect
of cellular homeostasis, and defects in this process have been linked to aging, degenerative …

Several studies reported that mitochondrial stress induces cytosolic proteostasis. How
mitochondrial stress activates proteostasis in the cytosol remains unclear. However, the …

Mitochondria are cellular organelles responsible for generation of chemical energy in the
process called oxidative phosphorylation. They originate from a bacterial ancestor and …

Mitochondria are involved in several vital functions of the eukaryotic cell. The majority of
mitochondrial proteins are coded by nuclear DNA. Constant import of proteins from the …

The biosynthesis of proteins entails a complex series of chemical reactions that transform
the information stored in the nucleic acid sequence into a polypeptide chain that needs to …

Size distribution in a group of differentiated cells often falls into a constant range. However,
in vitro and in vivo studies have shown that cells can temporarily change their size in …

Stem cells have the unique capacity to differentiate into many cell types during embryonic
development and postnatal growth. Through coordinated cellular behaviors (self‐renewal …

Throughout the animal kingdom, mitochondria are the only organelles that retain their own
genome and the transcription and translation machineries that are all essential for energy …