Immune cell differentiation and function are crucially dependent on specific metabolic
programs dictated by mitochondria, including the generation of ATP from the oxidation of …

Highlights•Mitochondrial dynamics depend on interactions with the cytoskeleton.•
Interactions with microtubules mediate motility, turnover, and organelle inheritance.• …

Mitochondria hold the key to many biological functions, ranging from the long-known role in
ATP production to metabolic control, cellular signaling and regulation of cell death …

According to multi-level theory, evolutionary transitions require mediating conflicts between
lower-level units in favour of the higher-level unit. By this view, the origin of eukaryotes and …

Cell proliferation is associated with a high rate of aerobic glycolysis, which has been widely
interpreted as a compensatory mechanism for suppressed mitochondrial function, despite …

Yeast physiology is temporally regulated, this becomes apparent under nutrient-limited
conditions and results in respiratory oscillations (YROs). YROs share features with circadian …

Throughout more than 1.5 billion years of obligate endosymbiotic co-evolution, mitochondria
have developed not only the capacity to control distinct molecular cascades leading to cell …

Mitochondrial ribosomes synthesize a subset of hydrophobic proteins required for assembly
of the oxidative phosphorylation complexes. This process requires temporal and spatial …

Organelle biosynthesis is a key requirement for cell growth and division. The regulation of
mitochondrial biosynthesis exhibits additional layers of complexity compared with that of …

The cytoplasm is an aqueous, highly crowded solution of active macromolecules. Its
properties influence the behavior of proteins, including their folding, motion, and …