The C3 toxin produced by Clostridium botulinum (C3bot) catalyzes the mono-ADP-
ribosylation of the small GTPases Rho A, B and C, resulting in their inactivation. Recently, a …

Clostridium botulinum adenosine diphosphate (ADP)-ribosyltransferase C3 was the first
bacterial exoenzyme/toxin found to act on small guanosine triphosphate (GTP) ases of the …

C3bot from Clostridium botulinum is a bacterial mono-ADP-ribosylating enzyme, which
transfers an ADP-ribose moiety onto the small GTPases Rho A/B/C. C3bot and the catalytic …

C3 protein toxins produced by Clostridium (C.) botulinum and C. limosum are mono-ADP-
ribosyltransferases, which specifically modify the GTPases Rho A/B/C in the cytosol of …

The C3 enzymes from Clostridium (C.) botulinum (C3bot) and Clostridium limosum (C3lim)
are single chain protein toxins of about 25 kDa that mono-ADP-ribosylate Rho-A,-B, and-C …

Background The C3bot1 protein (∼ 23 kDa) from Clostridium botulinum ADP-ribosylates
and thereby inactivates Rho. C3bot1 is selectively taken up into the cytosol of monocytes …

The binary Clostridium botulinum C2 toxin consists of two individual proteins, the transport
component C2II (80 kDa) and the enzyme component C2I, which ADP-ribosylates G-actin in …

The binary C2 toxin of Clostridium (C.) botulinum consists of two non-linked proteins, the
enzyme subunit C2I and the separate binding/transport subunit C2II. To exhibit toxic effects …

Clostridium botulinum exoenzyme C3 is the prototype of C3-like ADP-ribosyltransferases
that modify the GTPases RhoA, B, and C. C3 catalyzes the transfer of an ADP-ribose moiety …

Clostridium botulinum C2 toxin is a member of the family of binary actin-ADP-ribosylating
toxins. It consists of the enzyme component C2I, and the separated binding/translocation …