Albeit controversely discussed, it has been suggested by several authors that nitric oxide
(NO) serves as a permissive factor in the cerebral blood flow response to systemic …

Background and Purpose Concentration of hydrogen ions is an important regulator of
cerebral arterial tone under physiological and pathological conditions. Previous studies …

Background and Purpose—During cerebral ischemia, both hypoxia and hypercapnia
appear to produce marked dilatation of the cerebral arteries. Hypercapnia and hypoxia may …

Mechanisms for secondary sustained increase in cerebral blood flow (CBF) during
prolonged hypercapnia are unknown. We show that induction of endothelial NO synthase …

Background and Purpose—Potassium channels or nitric oxide or both are major mediators
of acidosis-induced dilation in the cerebral circulation. However, these contributions depend …

Background and Purpose The role of nitric oxide in cerebrovascular response to changes in
Pco2 is unclear. In the present study, we assessed responses at two levels of hypercapnia in …

Rationale: Acidosis is a powerful vasodilator signal in the brain circulation. However, the
mechanisms by which this response occurs are not well understood, particularly in the …

We studied the effect of nitro-L-arginine methyl ester (L-NAME), a nitric oxide synthase
(NOS) inhibitor, on the increases in cerebral blood flow (CBF) elicited by stepwise elevations …

We tested the hypothesis that dilatation of cerebral arterioles during hypoxia is mediated by
activation of ATP-sensitive K+ channels. The diameter of pial arterioles was measured …

We tested the hypothesis that the CBF response to extracellular acidosis is mediated by
nitric oxide (NO). A closed cranial window, superfused with artificial CSF (aCSF), was …