COX-2 is upregulated at an early stage in colorectal carcinogenesis and generates
prostaglandins, which promote cancer cell proliferation, impair apoptosis and enhance …

Cyclooxygenase-2 (COX-2) is an inducible enzyme which triggers the biosynthesis of
prostaglandins. COX-2 is activated in response to inflammatory stimuli and is one of the …

Chemoprevention of colorectal cancer is a promising science that has particular importance
due to the limited success of current treatments for most advanced common malignancies …

The cyclooxygenase-2 (COX-2) enzyme has a fundamental role in the carcinogenesis of
colorectal cancer. The anticarcinogenic mechanisms of NSAIDs are not completely …

Cyclooxygenase (COX), a key enzyme in the prostanoid biosynthetic pathway, has received
considerable attention due to its role in human cancers. Observational and randomized …

Cyclooxygenase (COX)-2, an inducible enzyme involved in prostaglandin biosynthesis, has
attracted considerable attention recently, due to its role in human cancer biology. Several …

Colorectal cancer is a major cause of morbidity and mortality accounting for an estimated
550,000 deaths annually worldwide. Colonic neoplasia develops in a stepwise fashion …

Cyclooxygenase (COX) enzyme-dependent arachidonic acid metabolites occupy key
positions in important physiologic processes such as immunity, reproduction, and vascular …

Colorectal cancer (CRC) is one of the most common neoplasia in Western countries and the
second leading cause of cancer-related death. The vast majority of cases belong to sporadic …

The decisive epidemiological observation that non-steroidal anti-inflammatory drugs
(NSAIDs) prevent colon and possibly other cancers as well has spurred novel approaches to …