Chemical Exchange Saturation Transfer Magnetic Resonance Imaging Identifies Abnormal Calf Muscle–Specific Energetics in Peripheral Artery Disease

HL Sporkin, TR Patel, Y Betz, R Mathew… - Circulation …, 2022 - Am Heart Assoc
Background: Peripheral artery disease (PAD) results in exercise-induced ischemia in leg
muscles. 31Phosphorus (P) magnetic resonance spectroscopy demonstrates prolonged …

[HTML][HTML] Chemical Exchange Saturation Transfer MRI Identifies Abnormal Calf Muscle-Specific Energetics in Peripheral Artery Disease

HL Sporkin, TR Patel, Y Betz, R Mathew… - Circulation …, 2022 - ncbi.nlm.nih.gov
Background: Peripheral artery disease (PAD) results in exercise-induced ischemia in leg
muscles. 31 Phosphorus (P) magnetic resonance spectroscopy (MRS) demonstrates …

Dynamic magnetic resonance measurements of calf muscle oxygenation and energy metabolism in peripheral artery disease

AJ Bakermans, CH Wessel, KH Zheng… - Journal of Magnetic …, 2020 - Wiley Online Library
Background Clinical assessments of peripheral artery disease (PAD) severity are insensitive
to pathophysiological changes in muscle tissue oxygenation and energy metabolism distal …

Calf muscle perfusion at peak exercise in peripheral arterial disease: measurement by first‐pass contrast‐enhanced magnetic resonance imaging

DC Isbell, FH Epstein, X Zhong… - Journal of Magnetic …, 2007 - Wiley Online Library
Purpose To develop a contrast‐enhanced magnetic resonance (MR) technique to measure
skeletal muscle perfusion in peripheral arterial disease (PAD). Materials and Methods A total …

Exercise-induced calf muscle hyperemia: quantitative mapping with low-dose dynamic contrast enhanced magnetic resonance imaging

JL Zhang, G Layec, C Hanrahan… - American Journal …, 2019 - journals.physiology.org
Peripheral artery disease (PAD) in the lower extremities often leads to intermittent
claudication. In the present study, we proposed a low-dose DCE MRI protocol for quantifying …

Phosphocreatine kinetics in the calf muscle of patients with bilateral symptomatic peripheral arterial disease during exhaustive incremental exercise

R Esterhammer, M Schocke, O Gorny, L Posch… - Molecular Imaging and …, 2008 - Springer
Purpose To investigate the relationship between the atherosclerotic lesion load determined
on magnetic resonance angiography (MRA) and phosphocreatine (PCr) kinetics during …

Reproducibility of contrast-enhanced calf perfusion MRI measures in peripheral arterial disease

RS Jiji, AM West, FH Epstein, PF Antkowiak, CH Meyer… - 2011 - Am Heart Assoc
Background: Contrast-enhanced (CE) calf perfusion MRI at peak exercise (Ex) distinguishes
normal subjects from peripheral arterial disease (PAD) patients. Perfusion at rest can now …

Delayed calf muscle phosphocreatine recovery after exercise identifies peripheral arterial disease

DC Isbell, SS Berr, AY Toledano, FH Epstein… - Journal of the American …, 2006 - jacc.org
Objectives: In this study we intend to characterize phosphocreatine (PCr) recovery kinetics
with phosphorus-31 (31P) magnetic resonance spectroscopy in symptomatic peripheral …

Mouse skeletal muscle creatine chemical exchange saturation transfer (CrCEST) imaging at 11.7 T MRI

Y Takahashi, S Saito, H Kioka, R Araki… - Journal of Magnetic …, 2020 - Wiley Online Library
Background Creatine chemical exchange saturation transfer (CrCEST) imaging is expected
to be a novel evaluation method of muscular energy metabolism. Purpose To develop …

A pilot study of Ratiometric Creatine CEST MRI assessment of rabbit skeletal muscle energy metabolism at 3 T

J Zhao, G Wu, Q Wu, P Gong, J Kuang… - Journal of Magnetic …, 2024 - Wiley Online Library
Background pH MRI may provide useful information to evaluate metabolic disruption
following ischemia. Radiofrequency amplitude‐based creatine chemical exchange …