Activation of the p38 mitogen-activated protein kinase (MAPK) pathway induces
inflammation, apoptosis, and fibrosis. However, little is known of the contribution of the …

The mitogen-activated protein kinase (MAPK) signaling pathways play essential roles in cell
proliferation and differentiation. Recent studies also show the activation of MAPK signaling …

Ischemia followed by reperfusion has a number of clinically significant consequences. A
number of pathophysiological processes appear to be involved in ischemia/reperfusion (I/R) …

The long-standing notion that the course of acute kidney injury (AKI) is unalterable and
portends poor outcomes for patients seems poised to change. 1 Several new diagnostic …

Oxidative stress is an underlying component of acute and chronic kidney disease. Apoptosis
signal–regulating kinase 1 (ASK1) is a widely expressed redox-sensitive serine threonine …

The extracellular signal-regulated kinase 1/2 (ERK1/2) cascade is the prototype mammalian
mitogen-activated protein kinase (MAPK) signaling cascade that regulates a number of …

p38 mitogen-activated protein kinase (MAPK) signaling promotes diabetic kidney injury.
Apoptosis signal-regulating kinase (ASK) 1 is one of the upstream kinases in the p38 MAPK …

The mitogen-activated protein kinase (MAPK) cascade plays an important role in the
regulation of various cellular functions in glomerulonephritis (GN). Here, we investigated …

Background: Chronic kidney disease (CKD) is a condition increasingly affecting millions of
individuals worldwide and is ranked as the ninth leading cause of death in the United States …

Simple Summary The mitogen-activated protein kinase (MAPK) pathway plays a crucial role
in inflammatory and malignant diseases. The MAPK signaling cascade is mediated by …