Presents a series of articles about cell signal transduction through mitogen-activated protein
(MAP) kinase pathway. Inclusion of parallel series of MAP kinase cascades that link signal …

Simple Summary The mitogen-activated protein kinase (MAPK) pathway plays a crucial role
in inflammatory and malignant diseases. The MAPK signaling cascade is mediated by …

Aims The mitogen-activated protein kinase (MAPK) cascades integrate various upstream
signals to regulate many cellular functions, including proliferation, differentiation, and …

While the serine/threonine protein kinase Akt has attracted attention as a mediator of
survival (anti-apoptotic) signal, the regulation and function of the PI3-kinase-Akt pathway in …

Expression of mitogen-activated protein kinases in human renal dysplasia. Background We
previously reported that the expression of mitogen-activated protein kinases (MAPKs) is …

Diabetic kidney disease (DKD) is the most common cause of severe renal disease
worldwide and the single strongest predictor of mortality in diabetes patients. Kidney …

While mitogen-activated protein kinase (MAPK) activation has been implicated in the
pathogenesis of various glomerular diseases, including nephrotic syndrome (NS), its …

The mitogen-activated protein kinase (MAPK) signalling pathways play pivotal roles in
cellular processes such as proliferation, apoptosis, gene regulation, differentiation, and cell …

Mitogen-activated protein kinase (MAPK) cascades contain a trio of kinases, MAPK kinase
kinase (MKKK)→ MAPK kinase (MKK)→ MAPK, that mediate a variety of cellular responses …

The role of the MAP kinase, extracellular signal-regulated kinase 5 (ERK5) remains
unknown, however it is involved in cell differentiation and survival as highlighted by the …