Apoptosis is co-regulated by the conserved family of Bcl-2-related proteins, which includes
both its agonists (Bax) and antagonists (Bcl-XL). A mutant strain of the yeast Saccharomyces …

Bcl-2 family members are regulators of cell death. The precise biochemical properties of
these proteins are unclear although intrafamily protein-protein association is thought to be …

The pro-apoptotic protein Bax can homodimerize with itself and heterodimerize with the anti-
apoptotic protein Bcl-2, but the significance of these protein-protein interactions remains …

Bcl-2 and Bax are members of a family of cytoplasmic proteins that regulate apoptosis. The
two proteins have highly similar amino acid sequences but are functionally opposed: Bcl-2 …

The effects of the expression of the human Bcl-2 family proteins Bax, Bak, Bcl-2, and Bcl-XL
were examined in the fission yeast Schizosaccharomyces pombe and compared with Bax …

Cell death plays an important role in a number of physiological processes in all complex
multicellular organisms. One of the molecules that regulates this process is BAX, an integral …

The mammalian proapoptotic protein Bax confers a lethal phenotype when expressed in
yeast. By exploiting this phenotype, we have identified a novel human Bax inhibitor, BI-1. BI …

It has been suggested that BCL-2 family members associate with certain organelles through
their hydrophobic C-terminus which in the case of bcl-2, appears to play a key role in the …

In mammalian cells, the Bcl‐2 and Bcl‐x (L) proteins suppress programmed cell death
whereas the topographically similar Bax protein accelerates the apoptotic process. Recently …

The oncogene product Bcl-2 protects cells from apoptosis whereas its homolog Bax
functions to kill cells. Several binding partners of Bcl-2 and Bax have been isolated, but …