[HTML][HTML] Evasion of anti-growth signaling: A key step in tumorigenesis and potential target for treatment and prophylaxis by natural compounds

ARMR Amin, PA Karpowicz, TE Carey, J Arbiser… - Seminars in cancer …, 2015 - Elsevier
The evasion of anti-growth signaling is an important characteristic of cancer cells. In order to
continue to proliferate, cancer cells must somehow uncouple themselves from the many …

Resveratrol inhibits migration and Rac1 activation in EGF‐but not PDGF‐activated vascular smooth muscle cells

M Kumerz, EH Heiss, D Schachner… - Molecular nutrition & …, 2011 - Wiley Online Library
Scope: Migration of vascular smooth muscle cells (VSMC) reflects one of the initial steps in
atherosclerosis. Resveratrol (RV) is suggested to mediate putative vasoprotective properties …

Diet-derived polyphenols inhibit angiogenesis by modulating the interleukin-6/STAT3 pathway

S Lamy, N Akla, A Ouanouki, S Lord-Dufour… - Experimental cell …, 2012 - Elsevier
Several epidemiological studies have indicated that abundant consumption of foods from
plant origin is associated with a reduced risk of developing several types of cancers. This …

Low dose of penfluridol inhibits VEGF-induced angiogenesis

S Srivastava, FT Zahra, N Gupta, PE Tullar… - International Journal of …, 2020 - mdpi.com
Metastasis is considered a major burden in cancer, being responsible for more than 90% of
cancer-related deaths. Tumor angiogenesis is one of the main processes that lead to tumor …

Desalted Salicornia europaea extract attenuated vascular neointima formation by inhibiting the MAPK pathway-mediated migration and proliferation in vascular …

KJ Won, KP Lee, S Baek, L Cui, MH Kweon… - Biomedicine & …, 2017 - Elsevier
Salicornia europaea L.(SE) has been used as folk medicine for the treatment of various
diseases such as obesity, diabetes, and cancer. However, its effects on atherosclerotic …

Effects of flavonoid derivatives on human microvascular endothelial cells

E Bassino, S Antoniotti, F Gasparri… - Natural product …, 2016 - Taylor & Francis
Some natural compounds, including flavonoids, are active in vasculature re-growth during
hair follicle disruption, but their effects have not been yet evaluated directly on microvascular …

Red wine polyphenolic compounds inhibit vascular endothelial growth factor expression in vascular smooth muscle cells by preventing the activation of the p38 …

MH Oak, M Chataigneau, T Keravis… - … , and vascular biology, 2003 - Am Heart Assoc
Objective—Moderate consumption of red wine has a beneficial effect on the cardiovascular
system. This study examines whether red wine polyphenolic compounds (RWPCs) affect …

Morin inhibits PDGF-induced proliferation, migration, and invasion of vascular smooth muscle cells via modulating p27KIP1, AKT, and MMP-9 activities.

SS Shin, MC Ko, DH Noh, B Hwang, Y Park… - General Physiology …, 2018 - europepmc.org
Hyper-proliferation and migration of vascular smooth muscle cells (VSMCs) are closely
associated with atherosclerosis. Recently, the flavonol morin has been reported to exhibit …

Molecular structure‐function relationship of dietary polyphenols for inhibiting VEGF‐induced VEGFR‐2 activity

AB Cerezo, MS Winterbone, CWA Moyle… - Molecular nutrition & …, 2015 - Wiley Online Library
Scope We recently reported potent inhibition of VEGF signalling by two flavanols at sub‐
micromolar concentrations, mediated by direct binding of the flavanols to VEGF. The aim of …

Epigallocatechin-3-gallate inhibits proliferation of human aortic smooth muscle cells via up-regulating expression of mitofusin 2

Z Shu, M Yu, G Zeng, X Zhang, L Wu, X Tan - European Journal of Cell …, 2014 - Elsevier
Previous studies have shown that epigallocatechin-3-gallate (EGCG) inhibits the
proliferation of vascular smooth muscle cells (VSMCs) via the extracellular-signal-regulated …