Cellular senescence is a primary aging process and tumor suppressive mechanism
characterized by irreversible growth arrest, apoptosis resistance, production of a …

Cellular senescence represents a distinct cell fate characterized by replicative arrest in
response to a host of extrinsic and intrinsic stresses. Senescence facilitates programming …

Interlinked and fundamental aging processes appear to be a root-cause contributor to many
disorders and diseases. One such process is cellular senescence, which entails a state of …

Cellular senescence is a hallmark of aging defined by stable exit from the cell cycle in
response to cellular damage and stress. Senescent cells (SnCs) can develop a …

An increase in life expectancy in developed countries has led to a surge of chronic aging-
related diseases. In the last few decades, several studies have provided evidence of the …

Aging leads to a high burden on society, both medically and economically. Cellular
senescence plays an essential role in the initiation of aging and age-related diseases …

Highlights•Senescent cells contribute to aging and age-related diseases.•Reducing the
secretory phenotype of senescent cells (SASP) has beneficial effects.•Elimination of …

Cellular senescence, first described in vitro in 1961, has become a focus for biotech
companies that target it to ameliorate a variety of human conditions. Eminently characterized …

Much of the population is now faced with an enormous burden of age-associated chronic
diseases. Recent discoveries in geroscience indicate that healthspan in model organisms …

Aging is a natural but relentless process of physiological decline, leading to physical frailty,
reduced ability to respond to physical stresses (resilience) and, ultimately, organismal death …