The recent manuscript by Childs et al. in Nature Reviews Drug Discovery 1 thoroughly
reviewed the important role senescent cells play in driving ageing and age-related diseases …

Aging is characterized by progressive decay of biological systems and although it is not
considered a disease, it is one of the main risk factors for chronic diseases and many types …

Cellular senescence has historically been viewed as an irreversible cell-cycle arrest
mechanism that acts to protect against cancer, but recent discoveries have extended its …

Cellular senescence is a permanent state of cell cycle arrest that occurs in proliferating cells
subjected to different stresses. Senescence is, therefore, a cellular defense mechanism that …

Cellular senescence is a cell state implicated in various physiological processes and a wide
spectrum of age-related diseases. Recently, interest in therapeutically targeting senescence …

Cellular senescence suppresses cancer by irreversibly arresting cell proliferation.
Senescent cells acquire a proinflammatory senescence-associated secretory phenotype …

Along with a general decline in overall health, most chronic degenerative human diseases
are inherently associated with increasing age. Age-associated cognitive impairments and …

Aging is defined as a progressive decrease in physiological function accompanied by a
steady increase in mortality. The antagonistic pleiotropy theory proposes that aging is …

Population aging simultaneously highlights the remarkable advances in science, medicine,
and public policy, and the formidable challenges facing society. Indeed, aging is the primary …

Cellular senescence is a state of irreversible growth arrest characterized by hypertrophy and
secretion of various bioactive molecules, a phenomenon defined the Senescence …