Cellular senescence is a key component of human aging that can be induced by a range of
stimuli, including DNA damage, cellular stress, telomere shortening, and the activation of …

The progression of physiological ageing is driven by intracellular aberrations including
telomere attrition, genomic instability, epigenetic alterations and loss of proteostasis. These …

Senescent cells are induced by a wide variety of stimuli. They accumulate in several tissues
during aging, including the skin. Senescent cells secrete proinflammatory cytokines …

Highlights•Cellular senescence drives age-related decline of the musculoskeletal
system.•The Senescence Associated Secretory Phenotype (SASP) can chronically impair …

Almost half a century after the first reports describing the limited replicative potential of
primary cells in culture, there is now overwhelming evidence for the existence of “cellular …

Ageing is the biggest risk factor for impaired cardiovascular health, with cardiovascular
disease being the leading cause of death in 40% of individuals over 65 years old. Ageing is …

Here, we provide an overview of the importance of cellular fate in cancer as a group of
diseases of abnormal cell growth. Tumor development and progression is a highly dynamic …

Senolytics are a category of drugs that reduce the impact of cellular senescence, an effect
associated with a range of chronic and age‐related diseases. Since the discovery of the first …

The field of research on cellular senescence experienced a rapid expansion from being
primarily focused on in vitro aspects of aging to the vast territories of animal and clinical …

Ageing is the biggest risk factor for impaired cardiovascular health, with cardiovascular
disease being the cause of death in 40% of individuals over 65 years old. Ageing is …