[HTML][HTML] Biomaterial-mediated intracellular control of macrophages for cell therapy in pro-inflammatory and pro-fibrotic conditions

T Tylek, J Wong, AE Vaughan, KL Spiller - Biomaterials, 2024 - Elsevier
Macrophages are key modulators of all inflammatory diseases and essential for their
resolution, making macrophage cell therapy a promising strategy for regenerative medicine …

Modulation of macrophage phenotype via phagocytosis of drug‐loaded microparticles

KL Wofford, DK Cullen, KL Spiller - Journal of Biomedical …, 2019 - Wiley Online Library
Monocyte‐derived macrophages play a critical role in directing wound pathology following
injury. Depending on their phenotype, macrophages also promote tissue regeneration …

Biomaterial-mediated reprogramming of monocytes via microparticle phagocytosis for sustained modulation of macrophage phenotype

KL Wofford, BS Singh, DK Cullen, KL Spiller - Acta biomaterialia, 2020 - Elsevier
Monocyte-derived macrophages orchestrate tissue regeneration by homing to sites of injury,
phagocytosing pathological debris, and stimulating other cell types to repair the tissue …

Biomaterial-assisted macrophage cell therapy for regenerative medicine

S Sung, LA Steele, GE Risser, KL Spiller - Advanced drug delivery reviews, 2023 - Elsevier
Although most tissue types are capable of some form of self-repair and regeneration, injuries
that are larger than a critical threshold or those occurring in the setting of certain diseases …

Harnessing macrophage plasticity for tissue regeneration

TD Smith, RR Nagalla, EY Chen, WF Liu - Advanced drug delivery reviews, 2017 - Elsevier
Macrophages are versatile and plastic effector cells of the immune system, and contribute to
diverse immune functions including pathogen or apoptotic cell removal, inflammatory …

Drug delivery strategies to control macrophages for tissue repair and regeneration

R Garash, A Bajpai… - Experimental biology …, 2016 - journals.sagepub.com
Tissue repair and regeneration is a complex process. Our bodies have an excellent capacity
to regenerate damaged tissues in many situations. However, tissue healing is impaired in …

Biomaterials and bioactive factor delivery systems for the control of macrophage activation in regenerative medicine

PL Graney, EB Lurier, KL Spiller - ACS biomaterials science & …, 2017 - ACS Publications
Macrophages play an important role in tissue repair, regeneration, and the ability of
biomaterials to mediate these processes. Macrophages are highly plastic cells that exhibit …

Potential effects of biomaterials on macrophage function and their signalling pathways

F Zhu, S Wang, X Zhu, C Pang, P Cui, F Yang… - Biomaterials …, 2023 - pubs.rsc.org
The use of biomaterials in biomedicine and healthcare has increased in recent years.
Macrophages are the primary immune cells that induce inflammation and tissue repair after …

Biomaterials-mediated regulation of macrophage cell fate

Y Liu, T Segura - Frontiers in bioengineering and biotechnology, 2020 - frontiersin.org
Endogenous regeneration aims to rebuild and reinstate tissue function through enlisting
natural self-repairing processes. Promoting endogenous regeneration by reducing tissue …

Sustained release of drug-loaded nanoparticles from injectable hydrogels enables long-term control of macrophage phenotype

SS Soni, AM D'Elia, A Alsasa, S Cho, T Tylek… - Biomaterials …, 2022 - pubs.rsc.org
Injectable hydrogels may be pre-formed through dynamic crosslinks, allowing for injection
and subsequent retention in the tissue by shear-thinning and self-healing processes …