The PTEN tumour suppressor gene is mutated frequently in many malignancies and its
importance in the development of cancer is probably underestimated. As the primary …

The PTEN tumor suppressor was discovered by its homozygous deletion and other
mutations in cancer. Since then, PTEN has been shown to be a non-redundant …

PTEN is a potent tumour suppressor, and its loss of function is frequently observed in both
heritable and sporadic cancers. PTEN has phosphatase-dependent and phosphatase …

The tumor suppressor phosphatase and tensin homolog (PTEN) functions as a
phosphoinositide 3-phosphatase, that antagonizes phosphatidylinositol 3-kinase action, and …

The PTEN tumour suppressor protein is a phosphoinositide 3-phosphatase that, by
metabolising phosphatidylinositol 3, 4, 5-trisphosphate (PtdIns (3, 4, 5) P3), acts in direct …

The PTEN (phosphatase and tensin homologue deleted on chromosome 10) tumour
suppressor is a PI (phosphoinositide) 3-phosphatase that can inhibit cellular proliferation …

PTEN (also known as MMAC-1 or TEP-1) is one of the most frequently mutated tumor
suppressors in human cancer. It is also essential for embryonic development. PTEN …

The importance of PTEN in cellular function is underscored by the frequency of its
deregulation in cancer. PTEN tumor-suppressor activity depends largely on its lipid …

The tumour suppressor gene PTEN is mutated in a wide range of human cancers at a
frequency roughly comparable with p53. In addition, germline PTEN mutations are …

PTEN is a phosphatase which metabolises PIP 3, the lipid product of PI 3-Kinase, directly
opposing the activation of the oncogenic PI3K/AKT/mTOR signalling network. Accordingly …