In order to identify the molecular pathways governing melanoma and track its progression,
the next-generation sequencing (NGS) approach and targeted sequencing of cancer genes …

Background: Melanoma causes the greatest morbidity and mortality of all skin cancers.
Mucosal melanoma is a rare but highly aggressive neoplasm. According to previous studies …

Background: Malignant melanoma is a rare disease in Asia, and knowledge of the status
and the clinical significance of KIT and BRAF mutations in the Asian population is limited …

Purpose: A significant proportion of mucosal melanomas contain alterations in KIT. The aim
of this study was to characterize the pattern of KIT, NRAS, and BRAF mutations in mucosal …

Background Malignant melanoma of the female genital tract is relatively uncommon and
accounts for 3–7% of all melanoma localizations. This study aimed to identify driver genes in …

Background Mutations on KIT and downstream genes of MAPK pathway that overstimulate
cellular proliferation have been associated with primary oral and sinonasal melanomas …

KIT mutations play an important role during the pathogenesis of melanoma. Acral
melanoma, which is the most common type in China, is more likely to harbor activating KIT …

Background This study investigates the mutational profile of the KIT gene in primary and
metastatic melanomas, highlighting the significance of genetic heterogeneity. Methods This …

Melanoma can be stratified into unique subtypes based on distinct pathologies. The
acral/mucosal melanoma subtype is characterized by aberrant and constitutive activation of …

A 74-year-old male presented with rectal pain; workup uncovered an anal mass, and a
diagnosis of melanoma was rendered via histologic examination and immunohistochemical …