Purpose: Recent studies have shown activating KIT mutations in melanoma originating from
mucosa, acral, or cumulative sun-damaged skin sites. We aimed to assess the predictive …

This study aimed to evaluate the association of KIT mutations with clinicopathologic features
of melanomas using a meta-analysis and to identify differences between Asian and White …

Purpose: We recently identified a KIT exon 11 mutation in an anorectal melanoma of a
patient who had an excellent response to treatment with imatinib. To determine the …

Activating mutations in KIT are present in up to 20% of acral melanomas (AMs) or mucosal
melanomas, and 5% of melanoma associated with chronic sun-damaged skin. 1-5 In GI …

Stimulation of the c-Kit receptor tyrosine kinase has a critical role in the development and
migration of melanocytes, and oncogenic c-Kit mutants contribute to the progression of some …

Acral and mucosal melanoma are uncommon variants of melanoma. Acral melanoma has
an age-adjusted incidence of approximately 1.8 cases per million individuals per year …

Mucosal melanoma is a rare and aggressive subtype of melanoma that has a less favorable
prognosis due to the lack of understanding and identification of oncogenic drivers. Recently …

Yun J, Lee J, Jang J, Lee EJ, Jang KT, Kim JH, Kim K‐M. KIT amplification and gene
mutations in acral/mucosal melanoma in Korea. APMIS 2011; 119: 330–5. Mucosal and …

Oral mucosal melanoma (OMM) is a fatal sarcoma of unknown etiology. Histological
morphology and genetic events are distinct from those of its cutaneous counterpart. Mutation …

Mucosal melanoma is rare and accounts for 1.3–1.4% of all melanomas. Kit mutations are
found in approximately 15–20% of mucosal melanomas. Immunotherapy with anti cytotoxic …