Placental P-glycoprotein inhibition enhances susceptibility to Di-(2-ethylhexyl)-phthalate induced cardiac malformations in mice: A possibly promising target for …

C Tang, C Luo, Y Hua, K Zhou, H Duan, F Ma, Y Zhang… - Plos one, 2019 - journals.plos.org
Backgrounds Reducing toxicants transplacental rates could contribute to the prevention of
congenital heart defects (CHDs). Placental P-glycoprotein (P-gp) plays a vital role in fetal …

The effect of maternal exposure to di‐(2‐ethylhexyl)‐phthalate on fetal cardiac development in mice

C Tang, Y Deng, H Duan, Y Zhang, Y Li… - Journal of Applied …, 2018 - Wiley Online Library
Accumulating evidence has suggested a link between maternal di‐(2‐ethylhexyl)‐phthalate
(DEHP) exposure and various developmental abnormalities. However, the evidence …

[HTML][HTML] Prenatal di-(2-ethylhexyl) phthalate exposure induced myocardial cytotoxicity via the regulation of the NRG1-dependent ErbB2/ErbB4-PI3K/AKT signaling …

D Yu, D Zhu, X Wang, B Li, J Li, P Lu, Y Ji… - … and Environmental Safety, 2022 - Elsevier
Environmental sanitation of maternal contact during pregnancy is extremely important for the
development of different fetal tissues and organs. In particular, during early pregnancy, any …

Gestational di-(2-ethylhexyl) phthalate exposure causes fetal intrauterine growth restriction through disturbing placental thyroid hormone receptor signaling

Z Yu, Y Han, R Shen, K Huang, Y Xu, Q Wang, S Zhou… - Toxicology Letters, 2018 - Elsevier
Previous study reported that gestational Di-(2-ethylhexyl) phthalate (DEHP) exposure
caused fetal intrauterine growth restriction (IUGR). We aimed to investigate the role of …

Maternal exposure to di-(2-ethylhexyl) phthalate disrupts placental growth and development in pregnant mice

T Zong, L Lai, J Hu, M Guo, M Li, L Zhang… - Journal of hazardous …, 2015 - Elsevier
Abstract Di-(2-ethylhexyl) phthalate (DEHP) is used as a plasticizer and widely dispersed in
the environment. DEHP exposure reduces embryo implantations, increases embryonic loss …

Di-2-ethylhexyl phthalate induces heart looping disorders during zebrafish development

Y Sun, F Yang, Y Liu, M Yu, F Wu… - … and Industrial Health, 2021 - journals.sagepub.com
Di-2-ethylhexyl phthalate (DEHP) is a type of plasticizer widely used in industry. It is well-
known for its toxic effects to endocrine and reproductive systems and has been detected in …

Maternal di-(2-ethylhexyl) phthalate exposure during pregnancy causes fetal growth restriction in a stage-specific but gender-independent manner

R Shen, LL Zhao, Z Yu, C Zhang, YH Chen… - Reproductive …, 2017 - Elsevier
Abstract Di (2-ethylhexyl) phthalate (DEHP) is male developmental toxicant that impairs
testis development with reduced anogenital distance. The present study aimed to investigate …

Placental P-glycoprotein deficiency enhances susceptibility to chemically induced birth defects in mice

GR Lankas, LD Wise, ME Cartwright, T Pippert… - Reproductive …, 1998 - Elsevier
A subpopulation of the CF-1 mouse strain contains a spontaneous mutation in the P-
glycoprotein (Pgp) mdr1a gene, which leads to a lack of mdr1a expression in the placenta …

Maternal high-fat diet during pregnancy with concurrent phthalate exposure leads to abnormal placentation

A Kannan, J Davila, L Gao, S Rattan, JA Flaws… - Scientific reports, 2021 - nature.com
Abstract Di (2-ethylhexyl) phthalate (DEHP) is a synthetic chemical commonly used for its
plasticizing capabilities. Because of the extensive production and use of DEHP, humans are …

Prenatal exposure to phthalic acid induces increased blood pressure, oxidative stress, and markers of endothelial dysfunction in rat offspring

A Rahmani, K Soleimannejad… - Cardiovascular …, 2016 - Springer
Previous studies have reported the harmful effects of exposure to phthalic acid (PA) on
heart. No studies have reported the effects of prenatal PA exposure on the structure or …