Aging leads to large vessel arterial stiffening and endothelial dysfunction, which are
important determinants of cardiovascular risk. The aim of present work was to assess the …

Key points The results of the present study establish the temporal pattern of age‐related
vascular dysfunction across the adult lifespan in sedentary mice consuming a non‐Western …

Aortic stiffening is a major independent risk factor for cardiovascular diseases, cognitive
dysfunction, and other chronic disorders of aging. Mitochondria-derived reactive oxygen …

Mitochondrial dysregulation and associated excessive reactive oxygen species (mtROS)
production is a key source of oxidative stress in aging arteries that reduces baseline function …

Impairment of vascular function, in particular endothelial dysfunction and large elastic artery
stiffening, represents a major link between ageing and cardiovascular risk. Clinical and …

Objective—Age-related aortic stiffness is an independent risk factor for cardiovascular
diseases. Although oxidative stress is implicated in aortic stiffness, the underlying molecular …

Stiffening of large elastic arteries with age increases the risk of cardiovascular diseases
(CVD), but the underlying mechanisms are incompletely understood. We investigated the …

Background: The mechanisms underlying the perivascular adipose tissue (PVAT)
dysfunction in obesity are closely related to inflammation and oxidative stress. The present …

Aging is characterized by increased aortic stiffness, an early, independent predictor and
cause of cardiovascular disease. Oxidative stress from excess reactive oxygen species …

Aims In this study, we investigated the interaction between exercise-induced mitochondrial
adaptation of large vessels and the effects of chronic anabolic androgenic steroids (AASs) …