Hypermetabolism is a reality in amyotrophic lateral sclerosis compared to healthy subjects

P Fayemendy, B Marin, A Labrunie, Y Boirie… - Journal of the …, 2021 - Elsevier
Abstract Rationale Hypermetabolism (HM) in Amyotrophic lateral sclerosis (ALS) is the
reflection of a high energy metabolic level, but this alteration seems controversial. The main …

Malnutrition at the time of diagnosis is associated with a shorter disease duration in ALS

N Limousin, H Blasco, P Corcia, PH Gordon… - Journal of the …, 2010 - Elsevier
BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease.
During the course of the illness, malnutrition can occur and may shorten survival. The aim of …

Bioenergetic abnormalities in discrete cerebral motor pathways presage spinal cord pathology in the G93A SOD1 mouse model of ALS

SE Browne, L Yang, JP DiMauro, SW Fuller… - Neurobiology of …, 2006 - Elsevier
Multiple cell death pathways are implicated in the etiology of amyotrophic lateral sclerosis
(ALS), but the cause of the characteristic motor neuron degeneration remains unknown. To …

Hypermetabolism is a deleterious prognostic factor in patients with amyotrophic lateral sclerosis

P Jésus, P Fayemendy, M Nicol… - European Journal of …, 2018 - Wiley Online Library
Background and purpose The aim of this study was to investigate patients with amyotrophic
lateral sclerosis in order to determine their nutritional, neurological and respiratory …

Oxidative stress, neuroinflammation and mitochondria in the pathophysiology of amyotrophic lateral sclerosis

E Obrador, R Salvador, R López-Blanch… - Antioxidants, 2020 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron (MN) disease. Its primary
cause remains elusive, although a combination of different causal factors cannot be ruled …

Effect of high‐caloric nutrition on survival in amyotrophic lateral sclerosis

AC Ludolph, J Dorst, J Dreyhaupt… - Annals of …, 2020 - Wiley Online Library
Objective Weight loss has been identified as a negative prognostic factor in amyotrophic
lateral sclerosis, but there is no evidence regarding whether a high‐caloric diet increases …

Nutritional issues and supplements in amyotrophic lateral sclerosis and other neurodegenerative disorders

A Cameron, J Rosenfeld - Current Opinion in Clinical Nutrition & …, 2002 - journals.lww.com
Common or overlapping etiologies in disparate neurodegenerative diseases have led to the
promise that optimal nutritional care and the appropriate use of dietary supplements in …

Amyotrophic lateral sclerosis–looking for pathogenesis and effective therapy

E Naganska, E Matyja - Folia Neuropathologica, 2011 - termedia.pl
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease
characterized by loss of motor neurons in the spinal cord, brain stem and motor cortex which …

Nutritional management in amyotrophic lateral sclerosis: a worldwide perspective

V Silani, EJ Kasarskis, N Yanagisawa - Journal of neurology, 1998 - Springer
Although respiratory failure is the primary cause of death in patients with amyotrophic lateral
sclerosis (ALS), the management of nutritional status is important to enhancing the quality of …

Hypermetabolism in ALS is associated with greater functional decline and shorter survival

FJ Steyn, ZA Ioannides, RPA Van Eijk… - Journal of Neurology …, 2018 - jnnp.bmj.com
Objective To determine the prevalence of hypermetabolism, relative to body composition, in
amyotrophic lateral sclerosis (ALS) and its relationship with clinical features of disease and …