Protein degradation via the ubiquitin-proteasome pathway is important for a diverse number
of cellular processes ranging from cell signaling to development. Disruption of the ubiquitin …

Ubiquitin-activating enzyme is the archetype for a family of enzymes catalyzing the ATP-
coupled activation of ubiquitin and other class 1 ubiquitin-like proteins required for their …

Transfer of ubiquitin to substrate proteins regulates most processes in eukaryotic cells. E2
enzymes are a central component of the ubiquitin machinery, and generally determine the …

Ubiquitin-activating enzyme (UAE or E1) activates ubiquitin via an adenylate intermediate
and catalyzes its transfer to a ubiquitin-conjugating enzyme (E2). MLN4924 is an adenosine …

The mechanisms that regulate ubiquitin-mediated degradation of proteins such as the
mitotic cyclins at defined stages of the cell cycle are poorly understood. The initial step in the …

Individual members of the conserved family of ubiquitin conjugating enzymes (E2s) mediate
the ubiquitination and turnover of specific substrates of the ubiquitin-dependent degradation …

E3 ubiquitin ligases are a large family of proteins that, together with ubiquitin‐activating
enzyme E1 and ubiquitin‐conjugating enzyme E2, catalyze the ubiquitination of a variety of …

The ubiquitin-activating enzyme E1 catalyzes the first step in the ubiquitin conjugation
pathway. Previously, we have cloned and sequenced the cDNA for human E1. Expression of …

Modification of ubiquitin by phosphorylation extends the signaling possibilities of this
dynamic signal, as it could affect the activity of ligases and the processing of ubiquitin chains …

Ubiquitin (UB) is a protein modifier that regulates many essential cellular processes. To
initiate protein modification by UB, the E1 enzyme activates the C-terminal carboxylate of UB …