The immune system specifically recognizes and eliminates foreign antigens and, thus,
protects integrity of the host. During maturation of the immune system, tolerance …

Full article: Etiology of autoimmune disease: past, present and future Skip to Main Content
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Patients with autoimmune diseases may have a single one and its corresponding
autoantibodies, may have several distinct autoimmune diseases or, having one disease …

Educating the immune system to distinguish between self and non-self is critical to ensure
that an immune response is mounted against foreign antigens and not against self. A …

The mosaic of autoimmunity”. This complex interplay between the immune system and
various stimuli, that comprise the pebble of the mosaic, is controlled by a wide array of …

Monogenic autoimmune syndromes provide a rare yet powerful glimpse into the
fundamental mechanisms of immunologic tolerance. Such syndromes reveal not only the …

Rheumatologists see patients with a range of autoimmune diseases. Phenotyping these
diseases for diagnosis, prognosis and selection of therapies is an ever increasing problem …

A unique feature of the normal immune system is that, while being able to mount responses
to virtually all antigens of the environment, it also exhibits tolerance to its own components, a …

Autoimmune diseases classically present with a complex etiology in which different factors
concur in the generation and maintenance of autoreactive immune responses. Some …