Serotonin 5‐HT7 receptor overexpression in the raphe nuclei area produces antidepressive effect and affects brain serotonin system in male mice

AY Rodnyy, EM Kondaurova… - Journal of …, 2022 - Wiley Online Library
Abstract Heterodimerization between 5‐HT7 and 5‐HT1A receptors seems to play an
important role in the mechanism of depression and antidepressant drug action. It was …

5-HT1A/5-HT7 receptor interplay: Chronic activation of 5-HT7 receptors decreases the functional activity of 5-HT1A receptor and its сontent in the mouse brain

EM Kondaurova, DV Bazovkina, VS Naumenko - Molecular Biology, 2017 - Springer
Serotonin receptors 5-HT 1A and 5-HT 7 are involved in the development of various
psychopathologies. Some data indicate that there is an interplay between 5-HT 1A 5-HT 7 …

Possible involvement of 5-HT7 receptor in pathophysiology of affective disorders and action of antidepressant drugs

K Tokarski, M Kusek, J Sowa, B Bobula - Advances in Hygiene and …, 2014 - phmd.pl
The 5-HT7 receptor has recently received considerable attention since its involvement has
been implicated in cognitive disturbances, sleep and circadian rhythmicity disorders, anxiety …

5-HT7 receptor modulates GABAergic transmission in the rat dorsal raphe nucleus and controls cortical release of serotonin

M Kusek, J Sowa, K Kamińska… - Frontiers in Cellular …, 2015 - frontiersin.org
The 5-HT7 receptor is one of the several serotonin (5-HT) receptor subtypes that are
expressed in the dorsal raphe nucleus (DRN). Some earlier findings suggested that 5-HT7 …

Interplay between Serotonin 5‐HT1A and 5‐HT7 Receptors in Depressive Disorders

VS Naumenko, NK Popova, E Lacivita… - CNS neuroscience & …, 2014 - Wiley Online Library
Summary Serotonin (5‐hydroxytryptamine or 5‐HT) is an important neurotransmitter
regulating a wide range of physiological and pathological functions via activation of …

Alterations of expression of the serotonin 5-HT4 receptor in brain disorders

H Rebholz, E Friedman, J Castello - International Journal of Molecular …, 2018 - mdpi.com
The serotonin 4 receptor, 5-HT4R, represents one of seven different serotonin receptor
families and is implicated in a variety of physiological functions and their pathophysiological …

Cellular localization of serotonin2A (5HT2A) receptors in the rat brain

T Xu, SC Pandey - Brain research bulletin, 2000 - Elsevier
The serotonin2A (5HT2A) receptors have been shown to play an important role in several
psychiatric disorders, including depression, schizophrenia, and alcoholism. This …

5-HT7 receptor inhibition and inactivation induce antidepressantlike behavior and sleep pattern

PB Hedlund, S Huitron-Resendiz, SJ Henriksen… - Biological …, 2005 - Elsevier
BACKGROUND: The 5-hydroxytryptamine7 receptor (5-HT7) is implicated in circadian
rhythm phase resetting, and 5-HT7 receptor-selective antagonists alter rapid eye movement …

Antidepressant- and Anxiolytic-Like Effects of New Dual 5-HT1A and 5-HT7 Antagonists in Animal Models

K Pytka, A Partyka, M Jastrzębska-Więsek, A Siwek… - PLoS …, 2015 - journals.plos.org
The aim of this study was to further characterize pharmacological properties of two
phenylpiperazine derivatives: 1-{2-[2-(2, 6-dimethlphenoxy) ethoxy] ethyl}-4-(2 …

Receptor-genes cross-talk: effect of chronic 5-HT1A agonist 8-hydroxy-2-(di-n-propylamino) tetralin treatment on the expression of key genes in brain serotonin system …

NK Popova, VS Naumenko, AS Cybko, DV Bazovkina - Neuroscience, 2010 - Elsevier
Dysfunction in brain serotonin (5-HT) system has been implicated in the psychopathology of
anxiety, depression, drug addiction, and schizophrenia. The 5-HT1A receptors play a central …