Cytochrome P450 isoenzymes are pivotal in drug clearance. Part 1 of this two-part review,
published in the October issue of Drug Discovery Today, described the active site …

The development of the cytochrome P450 (P450) field has been remarkable in the areas of
pharmacology and toxicology, particularly in drug development. Today it is possible to use …

Cytochrome P450: Structure, Mechanism, and Biochemistry, third edition is a revision of a
review that summarizes the current state of research in the field of drug metabolism. The …

While new cytochrome P450 (CYP450) enzymes continue to be identified, it is now possible
to predict with some confidence the total number of human CYP450 enzymes. This review is …

Many members of the superfamily of hemeproteins, known as cytochrome P450 (P450 or
CYP), are currently described in the literature (over 2000 at the date of this writing)[see …

Cytochrome P450 isoenzymes are pivotal in drug clearance. Protein homology modelling
combined with studies on the structure and physico-chemistry of substrates is allowing the …

Isoform-selective cytochrome P450 inhibitors have greatly facilitated the characterization of
the catalytic specificities and pharmacological and toxicological significance of individual …

It is an honor to be the recipient of the 2002 Bernard B. Brodie Award in Drug Metabolism
from the American Society for Pharmacology and Experimental Therapeutics. In receiving …

Cytochrome P450 enzymes have major roles in the metabolism of steroids, drugs,
carcinogens, eicosanoids, and numerous other chemicals. The P450s are collectively …

ABSTRACT The cytochrome P450 (P450) field came out of interest in the metabolism of
drugs, carcinogens, and steroids, which remain major focal points. Over the years we have …