Abstract The B6. Sle1. Sle2. Sle3 triple congenic mouse (B6. TC) is a model of lupus
coexpressing the three major NZM2410-derived susceptibility loci on a C57BL/6 …

The Sle1 locus is a key determinant of lupus susceptibility in the NZM2410 mouse model.
Within Sle1, we have previously shown that Sle1a expression enhances activation levels …

Sle3 is an NZM2410-derived lupus susceptibility locus on murine chromosome 7. Congenic
recombination has resulted in a novel mouse strain, B6. Sle3, associated with serum …

Interplay between Foxp3+ regulatory T cells (Treg) and dendritic cells (DCs) maintains
immunologic tolerance, but the effects of each cell on the other are not well understood. We …

Dendritic cells (DC) control immunity and tolerance. Hence, we surmised that systemic lupus
erythematosus (SLE), a systemic autoimmune disease with autoreactive T and B cells, might …

Sle1 and Sle3 are 2 loci that confer susceptibility to lupus nephritis in the NZM2410 strain of
mice. Our previous work has shown that B6. NZMc1 mice, congenic for Sle1, exhibit loss of …

T cells contribute to the initiation and perpetuation of autoimmunity in systemic lupus
erythematosus (SLE), and seem to be directly involved in the development of related organ …

Lupus pathogenesis in the NZM2410 mouse model results from the expression of multiple
interacting susceptibility loci. Sle2 on chromosome 4 was significantly linked to …

Patients with systemic lupus erythematosus show an overexpression of type I IFN-
responsive genes that is referred to as “IFN signature.” We found that B6 …

Systemic lupus erythematosus (SLE) is a chronic, systemic autoimmune disease
characterized by the loss of tolerance to self-antigen. Because it is currently not known if …