The Src homology and collagen (Shc) proteins function as molecular adaptors in signaling
pathways mediated by a variety of cell surface receptors. Of the four mammalian Shc …

Shc (Src homology and collagen homology) proteins are considered prototypical signalling
adaptors in mammalian cells. Consisting of four unique members, ShcA, B, C and D, and …

The Src homologous and collagen‐like (SHC) protein plays an essential role in signal
transduction pathways in that it participates in the chain of events that leads to the activation …

The adaptor protein Shc (Src homology and collagen-containing protein) plays an important
role in the activation of signalling pathways downstream of RTKs (receptor tyrosine kinases) …

Src homology/collagen (SHC) proteins are thought to participate in signaling through both
receptor tyrosine kinases, such as the insulin receptor and the EGF (epidermal growth …

Immunoprecipitates of metabolically labeled PC12 cells consistently contained a 43-kDa
protein that was associated with Shc, a signal-transducing protein with a single SH2 domain …

The human Src homology and collagen (Shc) gene encodes three protein isoforms of 46,
52, and 66 kDa that belong to a family of molecular adapters involved in several signal …

Changes in protein-protein interactions may allow polypeptides to perform unexpected
regulatory functions. Mammalian ShcA docking proteins have amino-terminal …

Despite much progress in recent years, the precise signalling events triggered by the
vascular-endothelial-growth-factor (VEGF) receptors, fms-like tyrosine kinase (Flt1) and …

Src homology 2 (SH2) domains are the largest family of interaction modules encoded by the
human genome to recognize tyrosine-phosphorylated sequences and thereby play pivotal …