Shc has two distinct domains, amino-terminal and SH2 domain, which can interact with
activated growth factor receptors. Shc interacts with insulin receptor via Shc-amino-terminal …

Src homology 2 (SH2) domains are the largest family of interaction modules encoded by the
human genome to recognize tyrosine-phosphorylated sequences and thereby play pivotal …

Shc family proteins serve as phosphotyrosine adaptor molecules in various receptor-
mediated signaling pathways. In mammals, three distinct Shc genes have been described …

Shc proteins are implicated in coupling receptor tyrosine kinase to the mitogen-activated
protein kinase (MAPK) pathway by recruiting Grb2/SOS to the plasma membrane. To better …

Many of the signaling pathways regulating fetal lung mesenchymal cell proliferation are
mediated by the Shc intracellular signaling proteins. Shc is expressed as three isoforms: 52 …

Scleraxis (Scx) is a basic helix-loop-helix transcription factor that is expressed persistently in
tendons/ligaments, but transiently in entheseal cartilage. In this study, we generated a novel …

The adapter protein Shc was initially identified as an SH2 containing proto-oncogene
involved in growth factor signaling. Since then a number of studies in multiple systems have …

The Src kinase family comprises nine homologous members whose distinct expression
patterns and cellular distributions indicate that they have unique roles. These roles have not …

The Shc adaptor protein, hereafter referred to as ShcA, possesses two distinct
phosphotyrosine-recognition modules, a C-terminal Src homology 2 (SH2) domain and an N …

The Src homology 3 (SH3) region is a small protein domain present in a very large group of
proteins, including cytoskeletal elements and signaling proteins. It is believed that SH3 …