A new SH2-containing sequence, WC, was isolated by screening cDNA libraries with SH2
representative DNA probes. The WC cDNA is predicted to encode overlapping proteins of …

The Src-homology-3 domain (SH3) is an evolutionarily conserved, 50-to 60-amino-acid
module carried by intracellular proteins involved in the transduction of signals for cell …

The constitution and biophysical properties of extracellular matrices can dramatically
influence cellular phenotype during development, homeostasis, or pathogenesis. These …

Src-family kinases (SFKs) are non-receptor protein-tyrosine kinases involved in a variety of
signaling pathways in virtually every cell type. The SFKs share a common negative …

Background Signal transduction initiated by a wide variety of extracellular signals involves
the activation of protein-tyrosine kinases. Phosphorylated tyrosine residues in activated …

Src family kinases (SFKs) have been implicated as important regulators of ligand‐induced
cellular responses including proliferation, survival, adhesion and migration. Analysis of SFK …

In many ways the Src homology 3 (SH3) domain serves as the archetype for the ever-
growing family of modular protein binding domains. Much of what we know (or think we …

Shc is involved in the activation of Ras in response to many growth factors. Shc contains two
phosphotyrosine binding domains, an Src homology 2 (SH2) domain in the carboxyl …

SHB is an Src homology 2 domain‐containing adapter protein that has been found to be
involved in numerous cellular responses. We have generated an Shb knockout mouse. No …

Background Shc is the adaptor protein that exists in three isoforms, P46, P52 and P66, and
acts as a bridge between activated cell surface receptors and downstream signalling …