The members of the p130Cas (Cas) family are important scaffolding proteins that orchestrate
cell adhesion, migration and invasiveness downstream of integrin adhesion receptors and …

Shc proteins possess SH2 and PTB domains and serve a scaffolding function in signaling by
a variety of receptor tyrosine kinases. There are three known mammalian Shc genes, of …

The adaptor protein Shc has been implicated in Ras signaling via association with many
tyrosine-phosphorylated receptors, including growth factor receptors, antigen receptors on T …

Sc1 is an extracellular matrix-associated protein whose function is unknown. During early
embryonic development, Sc1 is widely expressed, and from embryonic day 12 (E12), Sc1 is …

A number of cDNAs (SC1, QR1, and hevin) have been shown to be similar to SPARC
(secreted protein acidic and rich in cysteine), a matricellular protein that regulates cell …

Defects in tendon patterning and differentiation are seldom assessed in mouse mutants due
to the difficulty in visualizing connective tissue structures. To facilitate tendon analysis, we …

The ShcA gene products have served as a model for the analysis of phosphotyrosine-
recognition domains, and for the functions of docking proteins during tyrosine kinase …

Src homology and collagen A (ShcA) is an adaptor protein that binds to tyrosine kinase
receptors. Its germ line deletion is embryonic lethal with abnormal cardiovascular system …

With the sequencing of an eukaryotic genome, it is possible to inventory the predicted
proteome for proteins that carry one or more Src Homology 3 (SH3) domains. Due to the …

c-Src and c-Yes are highly homologous members of the Src family of non-receptor tyrosine
kinases. The overall sequence similarity between c-Src and c-Yes allows them to perform …