An analysis of current mixture theory, policy, and practice was conducted by examining
standard reference texts, regulatory guidance documents, and journal articles. Although this …

Evaluation of potential human health hazards from exposure to chemical mixtures in the
environment presents one of the most difficult challenges for risk assessment as well as for …

This paper summarizes current challenges, the potential use of novel scientific
methodologies, and ways forward in the risk assessment and risk management of mixtures …

A major objective of combination toxicology is to establish whether a mixture of chemicals
will result in an effect similar to that expected on the basis of additivity. This requires …

Humans are exposed to multiple chemicals on a daily basis instead of to just a single
chemical, yet the majority of existing toxicity data comes from single-chemical exposure …

This paper describes the “quest” of our institute trying to assess the toxicology of chemical
mixtures. In this overview, we will discuss some critical developments in hazard identification …

This paper reviews the role of toxicological studies in understanding the health effects of
environmental exposures to mixtures. The approach taken is to review mixtures that have …

Some of the most challenging problems that toxicologists confront are determining how
biological effects of components in a complex mixture may interact, determining how these …

This paper reviews regulatory requirements and recent case studies to illustrate how the risk
assessment (RA) of chemical mixtures is conducted, considering both the effects on human …

The assessment of chemical mixtures is a complex topic for toxicologists, regulators, and the
public. In this article the linkage between the science of toxicology and the needs of …