Integrin Bidirectional Signaling: A Molecular View | PLOS Biology Skip to main content
Advertisement PLOS Biology Browse Current Issue Journal Archive Collections Find and …

Getting integrins into shape: recent insights into how integrin activity is regulated by
conformational changes | Journal of Cell Science | The Company of Biologists Skip to Main …

Integrins are adhesion molecules that convey signals both to and from the cytoplasm across
the plasma membrane. In resting cells, integrins in a low affinity state can be activated …

Adhesion receptors allow cells to interact with a dynamic and information-rich environment
of extracellular matrix molecules. The integrin family of adhesion receptors transduces …

Integrin-mediated cell adhesion regulates a vast number of biological processes including
migration, survival and proliferation of cells. It is therefore not surprising that defects in …

Cell-directed changes in the ligand-binding affinity ('activation') of integrins regulate cell
adhesion and migration, extracellular matrix assembly and mechanotransduction, thereby …

Integrins are cell adhesion receptors that couple extracellular divalent cation-dependent
recognition events with intracellular mechanical and biochemical responses and vice versa …

Integrins undergo global conformational changes that specify their activation state. Current
models portray the inactive receptor in a bent conformation that upon activation converts to a …

Conformational communication across the plasma membrane between the extracellular and
intracellular domains of integrins is beginning to be defined by structural work on both …

The cytoplasmic domains of integrin beta subunits are essential for the function of integrins
in cell adhesion and signaling. A chimera combining the transmembrane and cytoplasmic …