The ILSI/HESI Workshopon Alternatives to Carcinogenicity Testing aims to develop and
apply new methods for assessment of potential carcinogenic risk to humans from various …

Recent advances in quantitative cancer dose-response modeling include more biologically
based dose scales and high-to-low-dose extrapolation models, greater opportunity to …

Abstract The recent National Institute of Environmental Health Sciences/National Toxicology
Program Carcinogen Prediction Challenge elicited a valuable array of predictions of the …

A half century of experience notwithstanding, the chemical, pharmaceutical, and regulatory
communities continue to experience difficulty in quickly, economically, and most importantly …

The US Environmental Protection Agency has proposed new cancer risk assessment
guidelines (USEPA, 1996a) that will eventually replace the 1986 USEPA Guidelines for …

Value of information (VOI) analytic techniques are used to evaluate the benefit of performing
animal bioassays to provide information about the cancer potency of specific chemical …

Quantitative methods for estimation of cancer risk have been developed for daily, lifetime
human exposures. There are a variety of studies or methodologies available to address less …

In the early 1960s, the National Cancer Institute developed procedures to formalize the
process for the evaluation of the human risk of cancer from chemical exposure (Boorman …

Over 50 years, we have learned a great deal about the biology that underpins cancer but our
approach to testing chemicals for carcinogenic potential has not kept up. Only a small …

Risk assessment is broadly used as a regulatory tool by a number of federal and state
agencies. There has, however, been some controversy surrounding the broad application of …