The Group I metabotropic glutamate receptor 5 (mGluR5) can modulate addiction, pain, and
neuronal cell death. Expression of some mGluRs, such as Group II and III mGluRs, has been …

Microglial-related factors have been implicated in the signaling cascades that contribute to
neuronal cell death in various neurodegenerative disorders. Thus, strategies that reduce …

Objective Activation of metabotropic glutamate receptor 5 (mGluR5) has neuroprotective
properties in vitro and has been reported to limit postischemic lesion volume in vivo …

Decades of research dedicated toward Alzheimer's disease (AD) has culminated in much of
the current understanding of the neurodegeneration associated with disease. However …

We have previously shown that treatment with a mGluR5 positive allosteric modulator (PAM)
is neuroprotective after experimental traumatic brain injury (TBI), limiting post‐traumatic …

Metabotropic glutamate receptors (mGluRs) were previously shown to modulate several
essential functions in glial cells, including cell proliferation, glutamate uptake, neurotrophic …

Previous studies have demonstrated that human astrocytes express mRNA and receptor
protein for group I and II metabotropic glutamate receptors (mGluRs). Whether these …

A wealth of evidence has shown that microglia-associated neuro-inflammation is involved in
the secondary brain injury contributed to the poor outcome after traumatic brain injury (TBI) …

Recent evidence supports a role for metabotropic glutamate receptors (mGluRs) in
neuroinflammatory diseases. In the present study, we have investigated whether the group …

Activated microglia may be detrimental to neuronal survival in a number of
neurodegenerative diseases. Thus, strategies that reduce microglial neurotoxicity may have …